| Tag | Content |
|---|
| CPLM ID | CPLM-014492 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Carboxylesterase 1E |
Protein Synonyms/Alias | Carboxyesterase ES-3; ES-HTEL; Egasyn; Liver carboxylesterase 3; pI 5.5 esterase |
Gene Name | Ces1e |
Gene Synonyms/Alias | Ces1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 485 | ILRGGTSKEEINLSK | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. |
Sequence Annotation | MOTIF 558 561 Prevents secretion from ER (Potential).
ACT_SITE 221 221 Acyl-ester intermediate (By similarity).
ACT_SITE 353 353 Charge relay system (By similarity).
ACT_SITE 466 466 Charge relay system (By similarity).
CARBOHYD 79 79 N-linked (GlcNAc...) (Potential).
CARBOHYD 107 107 N-linked (GlcNAc...) (Potential).
CARBOHYD 489 489 N-linked (GlcNAc...) (Potential).
DISULFID 87 116 By similarity.
DISULFID 273 284 By similarity. |
Keyword | Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Hydrolase; Reference proteome; Serine esterase; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 561 AA |
Protein Sequence | MCLYALILVF LAAFTAGGHP SSLPVVDTLQ GKVLGKYVSL EGFTQPVAVF LGVPFAKPPL 60
GSLRFAPPQP AEPWSFVKNT TSYPPMCSQD PVAGQIVNDL LTNWEENISL QFSEDCLYLN 120
IYTPADLTKR DRLPVMVWIH GGGLVLGGAS TYDGLALSTH ENVVVVVIQY RLGIWGFFST 180
GDEHSRGNWG HLDQVAALHW VQDNIDNFGG DPGSVTIFGE SAGGESVSVL VLSPLAKNLF 240
HKAISESGVA LTAGLVKKNT RPLAEKIAVV SGCKSTTSAS MVHCLRQKTE EELLETTLKL 300
NLFSLDLHGD SRQSYPFVPT VLDGVVLPKM PEEILAEKDF NTVPYIVGIN KQEFGWILPT 360
MMNYPPSDMK LDPMTATSLL KKSSFLLNLP EEAIPVAVEK YLRHTDDPDR NKDQLLELIG 420
DVIFGVPSVI VSRGHRDAGA RTYMYEFQYR PSFSSKMKPS TVVGDHGDEI YSVFGAPILR 480
GGTSKEEINL SKMMMKFWAN FARNGNPNGQ GLPHWPEYDQ KEGYLQIGAT TQQAQKLKEK 540
EVAFWSELLA MKPLHAGHTE L 561 |
Gene Ontology | GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell. GO:0004091; F:carboxylesterase activity; IBA:RefGenome. GO:0080030; F:methyl indole-3-acetate esterase activity; IEA:EC. GO:0080032; F:methyl jasmonate esterase activity; IEA:EC. GO:0080031; F:methyl salicylate esterase activity; IEA:EC. GO:0016290; F:palmitoyl-CoA hydrolase activity; IDA:RGD. GO:0050253; F:retinyl-palmitate esterase activity; IEA:EC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |