UniProt Accession

 CP2CT_MOUSE; Q64458; E9QMD8; Q8WUN8 

Genbank Protein ID

 D17674; AC120840; AC139233; BC019908 

Genbank Nucleotide ID

 BAA04555.1; AAH19908.1 

Protein Name

 Cytochrome P450 2C29 

Protein Synonyms/Alias

 Aldehyde oxygenase; CYPIIC29; Cytochrome P-450 MUT-2 

Gene Name

 Cyp2c29 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
28	RQSSGRGKLPPGPTP	ubiquitination	[1]
105	GSFPMAEKIIKGFGV	ubiquitination	[1]
108	PMAEKIIKGFGVVFS	ubiquitination	[1]
192	NRFDYKDKEFLILMD	ubiquitination	[1]
200	EFLILMDKINENVKI	ubiquitination	[1]
235	GSHHKIVKNFNYLKS	ubiquitination	[1]
241	VKNFNYLKSYLLEKI	ubiquitination	[1]
247	LKSYLLEKIKEHKES	ubiquitination	[1]
252	LEKIKEHKESLDVTN	acetylation	[2]
252	LEKIKEHKESLDVTN	ubiquitination	[1]
270	FIDYYLIKQKQVNHI	acetylation	[3]
270	FIDYYLIKQKQVNHI	ubiquitination	[1]
322	KYPDVTAKVQEEIDR	ubiquitination	[1]
375	HAVTCDIKFRKYLIP	acetylation	[3]
375	HAVTCDIKFRKYLIP	ubiquitination	[1]
383	FRKYLIPKGTTVITS	ubiquitination	[1]
420	LNGNGNFKKSDYFMP	ubiquitination	[1]
421	NGNGNFKKSDYFMPF	ubiquitination	[1]
432	FMPFSTGKRICAGEG	ubiquitination	[1]
459	ILQNFKLKSLVHPKE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (EET). 

Sequence Annotation

 METAL 435 435 Iron (heme axial ligand) (By similarity).
 MOD_RES 252 252 N6-acetyllysine.  

Keyword

 Acetylation; Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 490 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro. 

Interpro

 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I.
 IPR008068; Cyt_P450_E_grp-I_CYP2B-like. 

Pfam

 PF00067; p450 

SMART

  

PROSITE

 PS00086; CYTOCHROME_P450 

PRINTS

 PR00463; EP450I.
 PR01685; EP450ICYP2B.
 PR00385; P450.