UniProt Accession

 AQP2_MOUSE; P56402; Q8VCG5; Q9R232 

Genbank Protein ID

 AF020519; AF105336; AY055468; BC019966 

Genbank Nucleotide ID

 AAB71414.1; AAD21017.1; AAL15462.1; AAH19966.1 

Protein Name

 Aquaporin-2 

Protein Synonyms/Alias

 AQP-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct 

Gene Name

 Aqp2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
238	QERLAVLKGLEPDTD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (By similarity). 

Sequence Annotation

 MOTIF 68 70 NPA 1.
 MOTIF 184 186 NPA 2.
 MOD_RES 256 256 Phosphoserine (By similarity).
 MOD_RES 261 261 Phosphoserine (By similarity).
 MOD_RES 264 264 Phosphoserine (By similarity).
 MOD_RES 269 269 Phosphoserine (By similarity).
 CARBOHYD 124 124 N-linked (GlcNAc...) (Potential).  

Keyword

 Cell membrane; Complete proteome; Cytoplasmic vesicle; Glycoprotein; Golgi apparatus; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 271 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
 GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
 GO:0030136; C:clathrin-coated vesicle; IEA:Compara.
 GO:0031410; C:cytoplasmic vesicle; IDA:MGI.
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005769; C:early endosome; IEA:Compara.
 GO:0070382; C:exocytic vesicle; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0031303; C:integral to endosome membrane; IC:MGI.
 GO:0005887; C:integral to plasma membrane; IC:MGI.
 GO:0005764; C:lysosome; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0055038; C:recycling endosome membrane; IC:MGI.
 GO:0005791; C:rough endoplasmic reticulum; IEA:Compara.
 GO:0005802; C:trans-Golgi network; IEA:Compara.
 GO:0015168; F:glycerol transmembrane transporter activity; IEA:Compara.
 GO:0015250; F:water channel activity; IDA:MGI.
 GO:0030042; P:actin filament depolymerization; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0006884; P:cell volume homeostasis; IEA:Compara.
 GO:0071280; P:cellular response to copper ion; IEA:Compara.
 GO:0071288; P:cellular response to mercury ion; IEA:Compara.
 GO:0042631; P:cellular response to water deprivation; IDA:MGI.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0006972; P:hyperosmotic response; IEA:Compara.
 GO:0072205; P:metanephric collecting duct development; IEP:UniProtKB.
 GO:0051928; P:positive regulation of calcium ion transport; IEA:Compara.
 GO:0003097; P:renal water transport; IMP:MGI.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0033762; P:response to glucagon stimulus; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0010226; P:response to lithium ion; IEA:Compara.
 GO:0009651; P:response to salt stress; IEA:Compara.
 GO:0042594; P:response to starvation; IEA:Compara. 

Interpro

 IPR023271; Aquaporin-like.
 IPR000425; MIP.
 IPR022357; MIP_CS. 

Pfam

 PF00230; MIP 

SMART

  

PROSITE

 PS00221; MIP 

PRINTS

 PR00783; MINTRINSICP.