| Tag | Content |
|---|
| CPLM ID | CPLM-021263 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cysteine/serine-rich nuclear protein 2 |
Protein Synonyms/Alias | CSRNP-2; Protein FAM130A1; TGF-beta-induced apoptosis protein 12; TAIP-12 |
Gene Name | CSRNP2 |
Gene Synonyms/Alias | C12orf22; FAM130A1; TAIP12 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 200 | HRIDAEEKQELRAIR | ubiquitination | [1] | | 234 | ACSQAGIKCQVDRMS | ubiquitination | [1] | | 281 | MKLELESKRQVSRPA | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May play a role in apoptosis. |
Sequence Annotation | |
Keyword | Activator; Apoptosis; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 543 AA |
Protein Sequence | MDAFTGSGLK RKFDDVDVGS SVSNSDDEIS SSDSADSCDS LNPPTTASFT PTSILKRQKQ 60
LRRKNVRFDQ VTVYYFARRQ GFTSVPSQGG SSLGMAQRHN SVRSYTLCEF AQEQEVNHRE 120
ILREHLKEEK LHAKKMKLTK NGTVESVEAD GLTLDDVSDE DIDVENVEVD DYFFLQPLPT 180
KRRRALLRAS GVHRIDAEEK QELRAIRLSR EECGCDCRLY CDPEACACSQ AGIKCQVDRM 240
SFPCGCSRDG CGNMAGRIEF NPIRVRTHYL HTIMKLELES KRQVSRPAAP DEEPSPTASC 300
SLTGAQGSET QDFQEFIAEN ETAVMHLQSA EELERLKAEE DSSGSSASLD SSIESLGVCI 360
LEEPLAVPEE LCPGLTAPIL IQAQLPPGSS VLCFTENSDH PTASTVNSPS YLNSGPLVYY 420
QVEQRPVLGV KGEPGTEEGS ASFPKEKDLN VFSLPVTSLV ACSSTDPAAL CKSEVGKTPT 480
LEALLPEDCN PEEPENEDFH PSWSPSSLPF RTDNEEGCGM VKTSQQNEDR PPEDSSLELP 540
LAV 543 |
Gene Ontology | GO:0005634; C:nucleus; IDA:UniProtKB. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0019902; F:phosphatase binding; IDA:UniProtKB. GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |