CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039389
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Calsequestrin 
Protein Synonyms/Alias
  
Gene Name
 Casq2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
40RVVSLSEKNLKQVLKacetylation[1]
43SLSEKNLKQVLKRYDacetylation[1]
289YEFLEILKQVARDNTacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction (By similarity). 
Sequence Annotation
  
Keyword
 Calcium; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 413 AA 
Protein Sequence
MKRIYLLVVG LYLLSFSRAE EGLNFPTYDG KDRVVSLSEK NLKQVLKRYD LLCLYYHEPV 60
SSDKVAQKQF QLKEIVLELV AQVLEHKNIG FVMVDSRKEA KLAKRLGFSE EGSLYVLKGG 120
RTIEFDGEFA ADVLVEFLLD LIEDPVEIVN NKLEVQAFER IEDQIKLLGF FKNEDSEYYK 180
AFQEAAEHFQ PYIKFFATFD KGVAKKLSLK MNEVGFYEPF MDEPSVIPNK PYTEEELVEF 240
VKEHQRPTLR RLRPEDMFET WEDDLNGIHI VAFAEKSDPD GYEFLEILKQ VARDNTDNPD 300
LSILWIDPDD FPLLVAYWEK TFKIDLFKPQ IGVVNVTDAD SVWMEIPDDD DLPTAEELED 360
WIEDVLSGKI NTEDDDNEDE DDDGDNDNDD DDDDDDNSDE DNDDSDDDDD DDE 413 
Gene Ontology
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:Compara.
 GO:0071313; P:cellular response to caffeine; IEA:Compara.
 GO:1901017; P:negative regulation of potassium ion transmembrane transporter activity; IEA:Compara.
 GO:0043267; P:negative regulation of potassium ion transport; IEA:Compara.
 GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Compara.
 GO:0010649; P:regulation of cell communication by electrical coupling; IEA:Compara.
 GO:0002027; P:regulation of heart rate; IEA:Compara.
 GO:0060306; P:regulation of membrane repolarization; IEA:Compara.
 GO:0051208; P:sequestering of calcium ion; IEA:Compara. 
Interpro
 IPR001393; Calsequestrin.
 IPR018233; Calsequestrin_CS.
 IPR012336; Thioredoxin-like_fold. 
Pfam
 PF01216; Calsequestrin 
SMART
  
PROSITE
 PS00863; CALSEQUESTRIN_1
 PS00864; CALSEQUESTRIN_2 
PRINTS
 PR00312; CALSEQUESTRN.