UniProt Accession

 FKH1_YEAST; P40466; D6VVF6; Q45U14 

Genbank Protein ID

 L38848; DQ115392; Z38059; BK006942 

Genbank Nucleotide ID

 AAA60938.1; AAZ22496.1; CAA86147.1; DAA08422.1 

Protein Name

 Fork head protein homolog 1 

Protein Synonyms/Alias

  

Gene Name

 FKH1 

Gene Synonyms/Alias

 YIL131C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
13	REQKFSGKYSSYTAQ	acetylation	[1]
13	REQKFSGKYSSYTAQ	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

  

Sequence Annotation

 DOMAIN 76 142 FHA.
 DNA_BIND 302 393 Fork-head.  

Keyword

 Complete proteome; DNA-binding; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 484 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0000790; C:nuclear chromatin; IBA:RefGenome.
 GO:0005667; C:transcription factor complex; IBA:RefGenome.
 GO:0019237; F:centromeric DNA binding; IDA:SGD.
 GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:SGD.
 GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IDA:SGD.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:SGD.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0008134; F:transcription factor binding; IBA:RefGenome.
 GO:0071406; P:cellular response to methylmercury; IMP:SGD.
 GO:0006338; P:chromatin remodeling; IMP:SGD.
 GO:0007535; P:donor selection; IMP:SGD.
 GO:0007005; P:mitochondrion organization; IBA:RefGenome.
 GO:0031124; P:mRNA 3'-end processing; IMP:SGD.
 GO:2000221; P:negative regulation of pseudohyphal growth; IGI:SGD.
 GO:0034244; P:negative regulation of transcription elongation from RNA polymerase II promoter; IMP:SGD.
 GO:0060277; P:negative regulation of transcription involved in G1 phase of mitotic cell cycle; IGI:SGD.
 GO:0090419; P:negative regulation of transcription involved in G2/M-phase of mitotic cell cycle; IMP:SGD.
 GO:0090055; P:positive regulation of chromatin silencing at silent mating-type cassette; IMP:SGD.
 GO:0090282; P:positive regulation of transcription involved in G2/M-phase of mitotic cell cycle; IGI:SGD.
 GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0006369; P:termination of RNA polymerase II transcription; IMP:SGD. 

Interpro

 IPR000253; FHA_dom.
 IPR008984; SMAD_FHA_domain.
 IPR001766; TF_fork_head.
 IPR018122; TF_fork_head_CS.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00498; FHA
 PF00250; Fork_head 

SMART

 SM00339; FH
 SM00240; FHA 

PROSITE

 PS50006; FHA_DOMAIN
 PS00657; FORK_HEAD_1
 PS00658; FORK_HEAD_2
 PS50039; FORK_HEAD_3 

PRINTS

 PR00053; FORKHEAD.