UniProt Accession

 ICT1_MOUSE; Q8R035; A2A6T2; A2A6T3; Q3TUL0; Q9CTK1; Q9D1R3 

Genbank Protein ID

 AK003192; AK003286; AK160697; AL603828; AL627096; AL627096; AL603828; AL603828; AL627096; AL627096; AL603828; CH466558; CH466558; BC028523 

Genbank Nucleotide ID

 BAB22632.1; BAB22691.1; BAE35961.1; CAM13810.1; CAM13810.1; CAM22619.1; CAM22619.1; CAM13811.1; CAM13811.1; CAM22618.1; CAM22618.1; EDL34481.1; EDL34486.1; AAH28523.1 

Protein Name

 Peptidyl-tRNA hydrolase ICT1, mitochondrial 

Protein Synonyms/Alias

 Immature colon carcinoma transcript 1 protein homolog 

Gene Name

 Ict1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
60	KGADTAWKVPEHAKQ	acetylation	[1]
94	PGGQNVNKVNSKAEV	acetylation	[1]
98	NVNKVNSKAEVRFHL	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (By similarity). 

Sequence Annotation

  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Hydrolase; Mitochondrion; Protein biosynthesis; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 206 AA 

Protein Sequence

Gene Ontology

 GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
 GO:0004045; F:aminoacyl-tRNA hydrolase activity; ISS:UniProtKB.
 GO:0016150; F:translation release factor activity, codon nonspecific; ISS:UniProtKB.
 GO:0070126; P:mitochondrial translational termination; ISS:UniProtKB. 

Interpro

 IPR000352; Pep_chain_release_fac_I_II. 

Pfam

 PF00472; RF-1 

SMART

  

PROSITE

 PS00745; RF_PROK_I 

PRINTS