CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025615
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PLCG1 variant protein 
Protein Synonyms/Alias
  
Gene Name
 PLCG1 variant protein 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1063DARLTEGKIMERRKKubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Phosphoprotein; SH3 domain; Transducer. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1412 AA 
Protein Sequence
ESSAGLRAGW VDRERRALPP PSRLRPRLRP VWGSRGAGAA GRRAGVLPTG ARAPLFPAPK 60
RGGASGQPRP AALRPRPVSA CRSRRRVPLV CRLSLSPNLS RRRCACSRAV LACAAAAPSV 120
GAMAGAASPC ANGCGPGAPS DAEVLHLCRS LEVGTVMTLF YSKKSQRPER KTFQVKLETR 180
QITWSRGADK IEGAIDIREI KEIRPGKTSR DFDRYQEDPA FRPDQSHCFV ILYGMEFRLK 240
TLSLQATSED EVNMWIKGLT WLMEDTLQAP TPLQIERWLR KQFYSVDRNR EDRISAKDLK 300
NMLSQVNYRV PNMRFLRERL TDLEQRSGDI TYGQFAQLYR SLMYSAQKTM DLPFLEASTL 360
RAGERPELCR VSLPEFQQFL LDYQGELWAV DRLQVQEFML SFLRDPLREI EEPYFFLDEF 420
VTFLFSKENS VWNSQLDAVC PDTMNNPLSH YWISSSHNTY LTGDQFSSES SLEAYARCLR 480
MGCRCIELDC WDGPDGMPVI YHGHTLTTKI KFSDVLHTIK EHAFVASEYP VILSIEDHCS 540
IAQQRNMAQY FKKVLGDTLL TKPVEISADG LPSPNQLKRK ILIKHKKLAE GSAYEEVPTS 600
MMYSENDISN SIKNGILYLE DPVNHEWYPH YFVLTSSKIY YSEETSSDQG NEDEEEPKEV 660
SSSTELHSNE KWFHGKLGAG RDGRHIAERL LTEYCIETGA PDGSFLVRES ETFVGDYTLS 720
FWRNGKVQHC RIHSRQDAGT PKFFLTDNLV FDSLYDLITH YQQVPLRCNE FEMRLSEPVP 780
QTNAHESKEW YHASLTRAQA EHMLMRVPRD GAFLVRKRNE PNSYAISFRA EGKIKHCRVQ 840
QEGQTVMLGN SEFDSLVDLI SYYEKHPLYR KMKLRYPINE EALEKIGTAE PDYGALYEGR 900
NPGFYVEANP MPTFKCAVKA LFDYKAQRED ELTFTKSAII QNVEKQEGGW WRGDYGGKKQ 960
LWFPSNYVEE MVNPVALEPE REHLDENSPL GDLLRGVLDV PACQIAIRPE GKNNRLFVFS 1020
ISMASVAHWS LDVAADSQEE LQDWVKKIRE VAQTADARLT EGKIMERRKK IALELSELVV 1080
YCRPVPFDEE KIGTERACYR DMSSFPETKA EKYVNKAKGK KFLQYNRLQL SRIYPKGQRL 1140
DSSNYDPLPM WICGSQLVAL NFQTPDKPMQ MNQALFMTGR HCGYVLQPST MRDEAFDPFD 1200
KSSLRGLEPC AISIEVLGAR HLPKNGRGIV CPFVEIEVAG AEYDSTKQKT EFVVDNGLNP 1260
VWPAKPFHFQ ISNPEFAFLR FVVYEEDMFS DQNFLAQATF PVKGLKTGYR AVPLKNNYSE 1320
DLELASLLIK IDIFPAKENG DLSPFSGTSL RERGSDASGQ LFHGRAREGS FESRYQQPFE 1380
DFRISQEHLA DHFDSRERRA PRRTRVNGDN RL 1412 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0006629; P:lipid metabolic process; IEA:InterPro. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR011993; PH_like_dom.
 IPR001192; Pinositol_PLipase_C.
 IPR017946; PLC-like_Pdiesterase_TIM-brl.
 IPR001849; Pleckstrin_homology.
 IPR015359; PLipase_C_EF-hand-like.
 IPR000909; PLipase_C_PInositol-sp_X_dom.
 IPR001711; PLipase_C_Pinositol-sp_Y.
 IPR000980; SH2.
 IPR001452; SH3_domain. 
Pfam
 PF00168; C2
 PF09279; efhand_like
 PF00388; PI-PLC-X
 PF00387; PI-PLC-Y
 PF00017; SH2
 PF00018; SH3_1 
SMART
 SM00239; C2
 SM00233; PH
 SM00148; PLCXc
 SM00149; PLCYc
 SM00252; SH2
 SM00326; SH3 
PROSITE
 PS50004; C2
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50003; PH_DOMAIN
 PS50007; PIPLC_X_DOMAIN
 PS50008; PIPLC_Y_DOMAIN
 PS50001; SH2
 PS50002; SH3 
PRINTS
 PR00390; PHPHLIPASEC.
 PR00401; SH2DOMAIN.
 PR00452; SH3DOMAIN.