UniProt Accession

 HRSL3_MOUSE; Q8R3U1; B7X6T3; Q3V3C3; Q8BWF7 

Genbank Protein ID

 AB298806; AK039703; AK042007; AK052657; AK163505; CH466612; CH466612; BC024581 

Genbank Nucleotide ID

 BAH08635.1; BAE20550.1; BAE20615.1; BAC35085.1; BAE37375.1; EDL33312.1; EDL33314.1; AAH24581.1 

Protein Name

 HRAS-like suppressor 3 

Protein Synonyms/Alias

 HRSL3; Group XVI phospholipase A1/A2; H-rev 107 protein 

Gene Name

 Pla2g16 

Gene Synonyms/Alias

 H-rev107; Hrasls3; Hrev107 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
91	YTPLPLSKIIQRAER	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE) (By similarity). For most substrates, PLA1 activity is much higher than PLA2 activity (By similarity). Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue. N- and O-acylation activity is hardly detectable (By similarity). Also has weak lysophospholipase activity. 

Sequence Annotation

 ACT_SITE 23 23 By similarity.
 ACT_SITE 35 35 By similarity.
 ACT_SITE 113 113 Acyl-thioester intermediate (By  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Lipid degradation; Lipid metabolism; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 162 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0052740; F:1-acyl-2-lysophosphatidylserine acylhydrolase activity; IEA:EC.
 GO:0008970; F:phosphatidylcholine 1-acylhydrolase activity; IEA:EC.
 GO:0052739; F:phosphatidylserine 1-acylhydrolase activity; IEA:EC.
 GO:0004623; F:phospholipase A2 activity; IDA:UniProtKB.
 GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
 GO:0045786; P:negative regulation of cell cycle; IEA:Compara.
 GO:0008654; P:phospholipid biosynthetic process; IDA:UniProtKB. 

Interpro

 IPR007053; LRAT-like_dom. 

Pfam

 PF04970; LRAT 

SMART

  

PROSITE

  

PRINTS