UniProt Accession

 GRE2_YEAST; Q12068; D6W1R9 

Genbank Protein ID

 Z48239; Z74893; AY558040; BK006948 

Genbank Nucleotide ID

 CAA88277.1; CAA99172.1; AAS56366.1; DAA10635.1 

Protein Name

 NADPH-dependent methylglyoxal reductase GRE2 

Protein Synonyms/Alias

 Genes de respuesta a estres protein 2 

Gene Name

 GRE2 

Gene Synonyms/Alias

 YOL151W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
36	GSARSQEKAENLTEA	ubiquitination	[1]
70	AFDHVFQKHGKDIKI	acetylation	[2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Catalyzes the irreversible reduction of the cytotoxic compound methylglyoxal (MG) to (R)-lactaldehyde as an alternative to detoxification of MG by glyoxalase I GLO1. MG is synthesized via a bypath of glycolysis from dihydroxyacetone phosphate and is believed to play a role in cell cycle regulation and stress adaptation. 

Sequence Annotation

 MOD_RES 333 333 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; NADP; Nucleus; Oxidoreductase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 342 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0046568; F:3-methylbutanol:NAD(P) oxidoreductase activity; IMP:SGD.
 GO:0050662; F:coenzyme binding; IEA:InterPro.
 GO:0043892; F:methylglyoxal reductase (NADPH-dependent) activity; IDA:SGD.
 GO:0008204; P:ergosterol metabolic process; IMP:SGD.
 GO:0030447; P:filamentous growth; IMP:SGD. 

Interpro

 IPR001509; Epimerase_deHydtase.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF01370; Epimerase 

SMART

  

PROSITE

  

PRINTS