CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044167
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein kinase C beta type 
Protein Synonyms/Alias
  
Gene Name
 PRKCB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
14SDPYVKLKLIPDPKSubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 119 AA 
Protein Sequence
MDPNGLSDPY VKLKLIPDPK SESKQKTKTI KCSLNPEWNE TFRFQLKESD KDRRLSVEIW 60
DWDLTSRNDF MGSLSFGISE LQKASVDGWF KLLSQEEGEY FNVPVPPEGS EANEELRQK 119 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005246; F:calcium channel regulator activity; IEA:Compara.
 GO:0004697; F:protein kinase C activity; IEA:Compara.
 GO:0042113; P:B cell activation; IEA:Compara.
 GO:0050853; P:B cell receptor signaling pathway; IEA:Compara.
 GO:0006816; P:calcium ion transport; IEA:Compara.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0071322; P:cellular response to carbohydrate stimulus; IEA:Compara.
 GO:0010829; P:negative regulation of glucose transport; IEA:Compara.
 GO:0045766; P:positive regulation of angiogenesis; IEA:Compara.
 GO:0050861; P:positive regulation of B cell receptor signaling pathway; IEA:Compara.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IEA:Compara. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR020477; C2_dom.
 IPR018029; C2_membr_targeting. 
Pfam
 PF00168; C2 
SMART
 SM00239; C2 
PROSITE
 PS50004; C2 
PRINTS
 PR00360; C2DOMAIN.