CPLM-022952

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-022952

UniProt Accession

DPOG2_HUMAN; Q9UHN1; O00419; Q0IJ81; Q96GW2; Q9UK35; Q9UK94

Genbank Protein ID

AF142992; AF177201; AF184344; BC000913; BC009194; U94703

Genbank Nucleotide ID

AAD50382.1; AAD56640.1; AAD56542.1; AAH00913.2; AAH09194.1; AAC51321.1

Protein Name

DNA polymerase subunit gamma-2, mitochondrial

Protein Synonyms/Alias

DNA polymerase gamma accessory 55 kDa subunit; p55; Mitochondrial DNA polymerase accessory subunit; MtPolB; PolG-beta

Gene Name

POLG2

Gene Synonyms/Alias

MTPOLB

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
288	EEGRKGNKLYYNFPW	acetylation	[1]

Reference

[1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]

Functional Description

Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.

Sequence Annotation

Keyword

3D-structure; Complete proteome; Disease mutation; DNA replication; DNA-binding; DNA-directed DNA polymerase; Mitochondrion; Nucleotidyltransferase; Progressive external ophthalmoplegia; Reference proteome; Transferase; Transit peptide.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

485 AA

Protein Sequence

MRSRVAVRAC HKVCRCLLSG FGGRVDAGQP ELLTERSSPK GGHVKSHAEL EGNGEHPEAP 60
GSGEGSEALL EICQRRHFLS GSKQQLSRDS LLSGCHPGFG PLGVELRKNL AAEWWTSVVV 120
FREQVFPVDA LHHKPGPLLP GDSAFRLVSA ETLREILQDK ELSKEQLVAF LENVLKTSGK 180
LRENLLHGAL EHYVNCLDLV NKRLPYGLAQ IGVCFHPVFD TKQIRNGVKS IGEKTEASLV 240
WFTPPRTSNQ WLDFWLRHRL QWWRKFAMSP SNFSSSDCQD EEGRKGNKLY YNFPWGKELI 300
ETLWNLGDHE LLHMYPGNVS KLHGRDGRKN VVPCVLSVNG DLDRGMLAYL YDSFQLTENS 360
FTRKKNLHRK VLKLHPCLAP IKVALDVGRG PTLELRQVCQ GLFNELLENG ISVWPGYLET 420
MQSSLEQLYS KYDEMSILFT VLVTETTLEN GLIHLRSRDT TMKEMMHISK LKDFLIKYIS 480
SAKNV 485

Gene Ontology

GO:0000262; C:mitochondrial chromosome; TAS:ProtInc.
GO:0003887; F:DNA-directed DNA polymerase activity; NAS:UniProtKB.
GO:0003697; F:single-stranded DNA binding; NAS:UniProtKB.
GO:0006281; P:DNA repair; NAS:UniProtKB.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.

Interpro

IPR004154; Anticodon-bd.
IPR027031; Gly-tRNA_synthase/POLG2.
IPR027030; POLG2.

Pfam

PF03129; HGTP_anticodon

SMART

PROSITE

PRINTS