CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016267
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Liprin-beta-1 
Protein Synonyms/Alias
 Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1; PTPRF-interacting protein-binding protein 1; hSGT2 
Gene Name
 PPFIBP1 
Gene Synonyms/Alias
 KIAA1230 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
67EMMETDEKEGLRCQIubiquitination[1]
309DIEVQKMKKAVESLMacetylation[2]
322LMAANEEKDRKIEDLacetylation[2]
615DMSEPEFKRGGTRATubiquitination[1, 3]
646DLDMPFAKWTKEQVCubiquitination[1]
737DIGLPQYKTQFDEGRubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. 
Sequence Annotation
 DOMAIN 647 711 SAM 1.
 DOMAIN 719 782 SAM 2.
 DOMAIN 804 876 SAM 3.
 MOD_RES 37 37 Phosphoserine.
 MOD_RES 39 39 Phosphothreonine.
 MOD_RES 40 40 Phosphoserine.
 MOD_RES 309 309 N6-acetyllysine.
 MOD_RES 322 322 N6-acetyllysine.
 MOD_RES 466 466 Phosphoserine.
 MOD_RES 579 579 Phosphoserine.
 MOD_RES 601 601 Phosphoserine.
 MOD_RES 999 999 Phosphoserine.
 MOD_RES 1001 1001 Phosphoserine.
 MOD_RES 1003 1003 Phosphoserine.
 MOD_RES 1005 1005 Phosphothreonine.  
Keyword
 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1011 AA 
Protein Sequence
MMSDASDMLA AALEQMDGII AGSKALEYSN GIFDCQSPTS PFMGSLRALH LVEDLRGLLE 60
MMETDEKEGL RCQIPDSTAE TLVEWLQSQM TNGHLPGNGD VYQERLARLE NDKESLVLQV 120
SVLTDQVEAQ GEKIRDLEFC LEEHREKVNA TEEMLQQELL SRTSLETQKL DLMAEISNLK 180
LKLTAVEKDR LDYEDKFRDT EGLIQEINDL RLKVSEMDSE RLQYEKKLKS TKSLMAKLSS 240
MKIKVGQMQY EKQRMEQKWE SLKDELASLK EQLEEKESEV KRLQEKLVCK MKGEGVEIVD 300
RDIEVQKMKK AVESLMAANE EKDRKIEDLR QCLNRYKKMQ DTVVLAQGKD GEYEELLNSS 360
SISSLLDAQG FSDLEKSPSP TPVMGSPSCD PFNTSVPEEF HTTILQVSIP SLLPATVSME 420
TSEKSKLTPK PETSFEENDG NIILGATVDT QLCDKLLTSS LQKSSSLGNL KKETSDGEKE 480
TIQKTSEDRA PAESRPFGTL PPRPPGQDTS MDDNPFGTRK VRSSFGRGFF KIKSNKRTAS 540
APNLAETEKE TAEHLDLAGA SSRPKDSQRN SPFQIPPPSP DSKKKSRGIM KLFGKLRRSQ 600
STTFNPDDMS EPEFKRGGTR ATAGPRLGWS RDLGQSNSDL DMPFAKWTKE QVCNWLMEQG 660
LGSYLNSGKH WIASGQTLLQ ASQQDLEKEL GIKHSLHRKK LQLALQALGS EEETNHGKLD 720
FNWVTRWLDD IGLPQYKTQF DEGRVDGRML HYMTVDDLLS LKVVSVLHHL SIKRAIQVLR 780
INNFEPNCLR RRPSDENTIA PSEVQKWTNH RVMEWLRSVD LAEYAPNLRG SGVHGGLMVL 840
EPRFNVETMA QLLNIPPNKT LLRRHLATHF NLLIGAEAQH QKRDAMELPD YVLLTATAKV 900
KPKKLAFSNF GNLRKKKQED GEEYVCPMEL GQASGSASKK GFKPGLDMRL YEEDDLDRLE 960
QMEDSEGTVR QIGAFSEGIN NLTHMLKEDD MFKDFAARSP SASITDEDSN V 1011 
Gene Ontology
 GO:0005886; C:plasma membrane; NAS:ProtInc.
 GO:0007155; P:cell adhesion; TAS:ProtInc. 
Interpro
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR011510; SAM_2.
 IPR021129; SAM_type1. 
Pfam
 PF00536; SAM_1
 PF07647; SAM_2 
SMART
 SM00454; SAM 
PROSITE
 PS50105; SAM_DOMAIN 
PRINTS