CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023159
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc transporter ZIP10 
Protein Synonyms/Alias
 Solute carrier family 39 member 10; Zrt- and Irt-like protein 10; ZIP-10 
Gene Name
 SLC39A10 
Gene Synonyms/Alias
 KIAA1265; ZIP10 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
50MTELEPSKFSKQAAEubiquitination[1, 2]
53LEPSKFSKQAAENEKubiquitination[3]
66EKKYYIEKLFERYGEubiquitination[1, 2]
390LLVEDINKDKNLVPEubiquitination[3]
533GKQKWFMKQNTEESTubiquitination[1, 2, 3, 4, 5]
562DSDWLQLKPLAGTDDubiquitination[3, 5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 May act as a zinc-influx transporter. 
Sequence Annotation
 MOD_RES 536 536 Phosphothreonine.
 MOD_RES 553 553 Phosphothreonine.
 MOD_RES 591 591 Phosphoserine.
 CARBOHYD 139 139 N-linked (GlcNAc...) (Potential).
 CARBOHYD 198 198 N-linked (GlcNAc...) (Potential).
 CARBOHYD 218 218 N-linked (GlcNAc...) (Potential).
 CARBOHYD 339 339 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 831 AA 
Protein Sequence
MKVHMHTKFC LICLLTFIFH HCNHCHEEHD HGPEALHRQH RGMTELEPSK FSKQAAENEK 60
KYYIEKLFER YGENGRLSFF GLEKLLTNLG LGERKVVEIN HEDLGHDHVS HLDILAVQEG 120
KHFHSHNHQH SHNHLNSENQ TVTSVSTKRN HKCDPEKETV EVSVKSDDKH MHDHNHRLRH 180
HHRLHHHLDH NNTHHFHNDS ITPSERGEPS NEPSTETNKT QEQSDVKLPK GKRKKKGRKS 240
NENSEVITPG FPPNHDQGEQ YEHNRVHKPD RVHNPGHSHV HLPERNGHDP GRGHQDLDPD 300
NEGELRHTRK REAPHVKNNA IISLRKDLNE DDHHHECLNV TQLLKYYGHG ANSPISTDLF 360
TYLCPALLYQ IDSRLCIEHF DKLLVEDINK DKNLVPEDEA NIGASAWICG IISITVISLL 420
SLLGVILVPI INQGCFKFLL TFLVALAVGT MSGDALLHLL PHSQGGHDHS HQHAHGHGHS 480
HGHESNKFLE EYDAVLKGLV ALGGIYLLFI IEHCIRMFKH YKQQRGKQKW FMKQNTEEST 540
IGRKLSDHKL NNTPDSDWLQ LKPLAGTDDS VVSEDRLNET ELTDLEGQQE SPPKNYLCIE 600
EEKIIDHSHS DGLHTIHEHD LHAAAHNHHG ENKTVLRKHN HQWHHKHSHH SHGPCHSGSD 660
LKETGIANIA WMVIMGDGIH NFSDGLAIGA AFSAGLTGGI STSIAVFCHE LPHELGDFAV 720
LLKAGMTVKQ AIVYNLLSAM MAYIGMLIGT AVGQYANNIT LWIFAVTAGM FLYVALVDML 780
PEMLHGDGDN EEHGFCPVGQ FILQNLGLLF GFAIMLVIAL YEDKIVFDIQ F 831 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
 GO:0055085; P:transmembrane transport; TAS:Reactome.
 GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW. 
Interpro
 IPR003689; ZIP. 
Pfam
 PF02535; Zip 
SMART
  
PROSITE
  
PRINTS