UniProt Accession

 IEX1_HUMAN; P46695; Q5SU30; Q92691; Q93044 

Genbank Protein ID

 S81914; X96438; Y14551; BT006703; BA000025; AL662797; BC000844; BC005080 

Genbank Nucleotide ID

 AAB36278.1; CAA65304.1; CAA74886.1; AAP35349.1; BAB63319.1; CAI18210.1; AAH00844.1; AAH05080.1 

Protein Name

 Radiation-inducible immediate-early gene IEX-1 

Protein Synonyms/Alias

 Differentiation-dependent gene 2 protein; Protein DIF-2; Immediate early protein GLY96; Immediate early response 3 protein; PACAP-responsive gene 1 protein; Protein PRG1 

Gene Name

 IER3 

Gene Synonyms/Alias

 DIF2; IEX1; PRG1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
84	VEEPNPAKRLLFLLL	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. 

Sequence Annotation

 MOD_RES 18 18 Phosphothreonine; by MAPK1.
 MOD_RES 31 31 Phosphoserine.
 MOD_RES 123 123 Phosphothreonine; by MAPK1.
 MOD_RES 126 126 Phosphoserine; by MAPK1.
 CARBOHYD 133 133 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 156 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
 GO:0006915; P:apoptotic process; TAS:ProtInc.
 GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc.
 GO:0045820; P:negative regulation of glycolysis; IEA:Compara.
 GO:0050728; P:negative regulation of inflammatory response; IEA:Compara.
 GO:0003085; P:negative regulation of systemic arterial blood pressure; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0045732; P:positive regulation of protein catabolic process; IEA:Compara.
 GO:2000377; P:regulation of reactive oxygen species metabolic process; IEA:Compara.
 GO:2001020; P:regulation of response to DNA damage stimulus; IMP:MGI.
 GO:0001562; P:response to protozoan; IEA:Compara. 

Interpro

 IPR024829; IEX-1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS

 PR02100; GENEIEX1.