UniProt Accession

 EAF7_YEAST; P53911; D6W146 

Genbank Protein ID

 Z46843; Z71412; BK006947 

Genbank Nucleotide ID

 CAA86889.1; CAA96018.1; DAA10412.1 

Protein Name

 Chromatin modification-related protein EAF7 

Protein Synonyms/Alias

 ESA1-associated factor 7 

Gene Name

 EAF7 

Gene Synonyms/Alias

 YNL136W; N1212; N1843 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
343	REAEGKGKQIESEGG	acetylation	[1, 2]
381	DKNEPLAKRTRHSSS	acetylation	[2]
399	TSNETSPKRKRRKAG	acetylation	[2]
409	RRKAGSRKNSPPATR	acetylation	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] mChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases.
 Mitchell L, Huard S, Cotrut M, Pourhanifeh-Lemeri R, Steunou AL, Hamza A, Lambert JP, Zhou H, Ning Z, Basu A, Côté J, Figeys DA, Baetz K.
 Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1641-50. [PMID: 23572591] 

Functional Description

 Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. 

Sequence Annotation

 MOD_RES 200 200 Phosphoserine.  

Keyword

 Chromatin regulator; Coiled coil; Complete proteome; DNA damage; DNA repair; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 425 AA 

Protein Sequence

Gene Ontology

 GO:0035267; C:NuA4 histone acetyltransferase complex; IPI:SGD.
 GO:0006281; P:DNA repair; IDA:SGD.
 GO:0016573; P:histone acetylation; IPI:SGD.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR012423; EAF7. 

Pfam

 PF07904; Eaf7 

SMART

  

PROSITE

  

PRINTS