| Tag | Content |
|---|
| CPLM ID | CPLM-004193 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Selenocysteine-specific elongation factor |
Protein Synonyms/Alias | SelB translation factor |
Gene Name | selB |
Gene Synonyms/Alias | fdhA; b3590; JW3563 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 32 | ADRLPEEKKRGMTID | acetylation | [1] | | 247 | NIAGDAEKEQINRGD | acetylation | [1] | | 422 | VAARWQRKILDTLAT | acetylation | [1] | | 514 | WWVRDLAKETGTDEQ | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP. |
Sequence Annotation | NP_BIND 7 14 GTP (By similarity).
NP_BIND 57 61 GTP (By similarity).
NP_BIND 112 115 GTP (By similarity). |
Keyword | 3D-structure; Complete proteome; Cytoplasm; GTP-binding; Nucleotide-binding; Protein biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 614 AA |
Protein Sequence | MIIATAGHVD HGKTTLLQAI TGVNADRLPE EKKRGMTIDL GYAYWPQPDG RVPGFIDVPG 60
HEKFLSNMLA GVGGIDHALL VVACDDGVMA QTREHLAILQ LTGNPMLTVA LTKADRVDEA 120
RVDEVERQVK EVLREYGFAE AKLFITAATE GRGMDALREH LLQLPEREHA SQHSFRLAID 180
RAFTVKGAGL VVTGTALSGE VKVGDSLWLT GVNKPMRVRA LHAQNQPTET ANAGQRIALN 240
IAGDAEKEQI NRGDWLLADV PPEPFTRVIV ELQTHTPLTQ WQPLHIHHAA SHVTGRVSLL 300
EDNLAELVFD TPLWLADNDR LVLRDISARN TLAGARVVML NPPRRGKRKP EYLQWLASLA 360
RAQSDADALS VHLERGAVNL ADFAWARQLN GEGMRELLQQ PGYIQAGYSL LNAPVAARWQ 420
RKILDTLATY HEQHRDEPGP GRERLRRMAL PMEDEALVLL LIEKMRESGD IHSHHGWLHL 480
PDHKAGFSEE QQAIWQKAEP LFGDEPWWVR DLAKETGTDE QAMRLTLRQA AQQGIITAIV 540
KDRYYRNDRI VEFANMIRDL DQECGSTCAA DFRDRLGVGR KLAIQILEYF DRIGFTRRRG 600
NDHLLRDALL FPEK 614 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0019003; F:GDP binding; IDA:EcoCyc. GO:0005525; F:GTP binding; IDA:EcoCyc. GO:0003924; F:GTPase activity; IDA:EcoCyc. GO:0035368; F:selenocysteine insertion sequence binding; IDA:EcoCyc. GO:0003746; F:translation elongation factor activity; IEA:InterPro. GO:0000049; F:tRNA binding; IDA:EcoCyc. GO:0001514; P:selenocysteine incorporation; IMP:EcoCyc. GO:0016259; P:selenocysteine metabolic process; IMP:EcoCyc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |