UniProt Accession

 HXC6_HUMAN; P09630; B2RBV2; Q6DK09 

Genbank Protein ID

 S82986; M16938; AK314829; CH471054; BC074844; BC074845 

Genbank Nucleotide ID

 AAB46892.1; AAA36007.1; BAG37349.1; EAW96746.1; AAH74844.1; AAH74845.1 

Protein Name

 Homeobox protein Hox-C6 

Protein Synonyms/Alias

 Homeobox protein CP25; Homeobox protein HHO.C8; Homeobox protein Hox-3C 

Gene Name

 HOXC6 

Gene Synonyms/Alias

 HOX3C 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
198	NRRMKWKKESNLTST	acetylation	[1]
198	NRRMKWKKESNLTST	ubiquitination	[2]
221	TADSLGGKEEKREET	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. 

Sequence Annotation

 DNA_BIND 141 200 Homeobox.
 MOTIF 122 127 Antp-type hexapeptide.  

Keyword

 Alternative splicing; Complete proteome; Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 235 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0048706; P:embryonic skeletal system development; IEA:Compara.
 GO:0007275; P:multicellular organismal development; TAS:ProtInc.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001827; Homeobox_Antennapedia_CS.
 IPR017970; Homeobox_CS.
 IPR020479; Homeobox_metazoa.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 

Pfam

 PF00046; Homeobox 

SMART

 SM00389; HOX 

PROSITE

 PS00032; ANTENNAPEDIA
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 

PRINTS

 PR00024; HOMEOBOX.