CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027180
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FZD2 protein 
Protein Synonyms/Alias
  
Gene Name
 FZD2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
203GCEALMNKFGFQWPEubiquitination[1]
282FHCPRVLKVPSYLSYubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Developmental protein; Disulfide bond; G-protein coupled receptor; Membrane; Receptor; Transducer; Transmembrane; Transmembrane helix; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 641 AA 
Protein Sequence
ARGVSGCSVR PRQASGQAHR PLPRPASPTL RPRVKFAKRR GRRQPQRGGG GEEAQSPGWG 60
RGRGGRQGAG WGAAASMRPR SALPRLLLPL LLLPAAGPAQ FHGEKGISIP DHGFCQPISI 120
PLCTDIAYNQ TIMPNLLGHT NQEDAGLEVH QFYPLVKVQC SPELRFFLCS MYAPVCTVLE 180
QAIPPCRSIC ERARQGCEAL MNKFGFQWPE RLRCEHFPRH GAEQICVGQN HSEDGAPALL 240
TTAPPPGLQP GAGGTPGGPG GGGAPPRYAT LEHPFHCPRV LKVPSYLSYK FLGERDCAAP 300
CEPARPDGSM FFSQEETRFA RLWILTWSVL CCASTFFTVT TYLVDMQRFR YPERPIIFLS 360
GCYTMVSVAY IAGFVLQERV VCNERFSEDG YRTVVQGTKK EGCTILFMML YFFSMASSIW 420
WVILSLTWFL AAGMKWGHEA IEANSQYFHL AAWAVPAVKT ITILAMGQID GDLLSGVCFV 480
GLNSLDPLRG FVLAPLFVYL FIGTSFLLAG FVSLFRIRTI MKHDGTKTEK LERLMVRIGV 540
FSVLYTVPAT IVIACYFYEQ AFREHWERSW VSQHCKSLAI PCPAHYTPRM SPDFTVYMIK 600
YLMTLIVGIT SGFWIWSGKT LHSWRKFYTR LTNSRHGETT V 641 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
 GO:0042813; F:Wnt-activated receptor activity; IEA:Compara.
 GO:0007267; P:cell-cell signaling; IEA:Compara.
 GO:0090103; P:cochlea morphogenesis; IEA:Compara.
 GO:0030855; P:epithelial cell differentiation; IEA:Compara.
 GO:0060022; P:hard palate development; IEA:Compara.
 GO:0060119; P:inner ear receptor cell development; IEA:Compara.
 GO:0003149; P:membranous septum morphogenesis; IEA:Compara.
 GO:0003150; P:muscular septum morphogenesis; IEA:Compara.
 GO:0003151; P:outflow tract morphogenesis; IEA:Compara.
 GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IEA:Compara.
 GO:0007608; P:sensory perception of smell; IEA:Compara. 
Interpro
 IPR000539; Frizzled.
 IPR015526; Frizzled/SFRP.
 IPR020067; Frizzled_dom.
 IPR026550; FZD2.
 IPR017981; GPCR_2-like. 
Pfam
 PF01534; Frizzled
 PF01392; Fz 
SMART
 SM00063; FRI 
PROSITE
 PS50038; FZ
 PS50261; G_PROTEIN_RECEP_F2_4 
PRINTS
 PR00489; FRIZZLED.