CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022510
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Docking protein 5 
Protein Synonyms/Alias
 Downstream of tyrosine kinase 5; Insulin receptor substrate 6; IRS-6; IRS6 
Gene Name
 DOK5 
Gene Synonyms/Alias
 C20orf180 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
37VFKKASSKGPKRLEKacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. 
Sequence Annotation
 DOMAIN 8 112 PH.
 DOMAIN 132 237 IRS-type PTB.
 MOTIF 263 273 DKFBH motif.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 306 AA 
Protein Sequence
MASNFNDIVK QGYVRIRSRR LGIYQRCWLV FKKASSKGPK RLEKFSDERA AYFRCYHKVT 60
ELNNVKNVAR LPKSTKKHAI GIYFNDDTSK TFACESDLEA DEWCKVLQME CVGTRINDIS 120
LGEPDLLATG VEREQSERFN VYLMPSPNLD VHGECALQIT YEYICLWDVQ NPRVKLISWP 180
LSALRRYGRD TTWFTFEAGR MCETGEGLFI FQTRDGEAIY QKVHSAALAI AEQHERLLQS 240
VKNSMLQMKM SERAASLSTM VPLPRSAYWQ HITRQHSTGQ LYRLQDVSSP LKLHRTETFP 300
AYRSEH 306 
Gene Ontology
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005057; F:receptor signaling protein activity; IEA:Compara.
 GO:0000165; P:MAPK cascade; IEA:Compara.
 GO:0007399; P:nervous system development; IEA:Compara.
 GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:Compara. 
Interpro
 IPR002404; Insln_rcpt_S1.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF02174; IRS
 PF00169; PH 
SMART
 SM00233; PH
 SM00310; PTBI 
PROSITE
 PS51064; IRS_PTB
 PS50003; PH_DOMAIN 
PRINTS