| Tag | Content |
|---|
| CPLM ID | CPLM-017218 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/threonine-protein kinase Nek9 |
Protein Synonyms/Alias | Nercc1 kinase; Never in mitosis A-related kinase 9; NimA-related protein kinase 9 |
Gene Name | Nek9 |
Gene Synonyms/Alias | Nercc |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 731 | VEKVLNSKTIRSNSS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (By similarity). |
Sequence Annotation | DOMAIN 52 308 Protein kinase.
REPEAT 388 444 RCC1 1.
REPEAT 445 498 RCC1 2.
REPEAT 499 550 RCC1 3.
REPEAT 551 615 RCC1 4.
REPEAT 616 668 RCC1 5.
REPEAT 669 726 RCC1 6.
NP_BIND 58 66 ATP (By similarity).
REGION 732 896 Interaction with NEK6 (By similarity).
ACT_SITE 176 176 Proton acceptor (By similarity).
BINDING 81 81 ATP (By similarity).
MOD_RES 2 2 N-acetylserine (By similarity).
MOD_RES 2 2 Phosphoserine (By similarity).
MOD_RES 13 13 Phosphoserine (By similarity).
MOD_RES 16 16 Phosphoserine (By similarity).
MOD_RES 52 52 Phosphotyrosine (By similarity).
MOD_RES 76 76 Phosphoserine (By similarity).
MOD_RES 210 210 Phosphothreonine; by autocatalysis (By
MOD_RES 254 254 Phosphothreonine (By similarity).
MOD_RES 333 333 Phosphothreonine.
MOD_RES 741 741 Phosphoserine (By similarity).
MOD_RES 808 808 Phosphoserine (By similarity).
MOD_RES 839 839 Phosphoserine (By similarity).
MOD_RES 891 891 Phosphothreonine (By similarity).
MOD_RES 949 949 Phosphoserine (By similarity).
MOD_RES 983 983 Phosphoserine (By similarity). |
Keyword | Acetylation; ATP-binding; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 984 AA |
Protein Sequence | MSVLGEYERH CDSINSDFGS ESGGGGDSGP GPSAVPGPRA GGGAAEQEEL HYIPIRVLGR 60
GAFGEATLYR RTEDDSLVVW KEVDLTRLSE KERRDALNEI VILALLQHDN IIAYYNHFMD 120
NTTLLIELEY CNGGNLYDKI LRQKDKLFEE EMVVWYLFQI VSAVSCIHKA GILHRDIKTL 180
NIFLTKANLI KLGDYGLAKK LNSEYSMAET LVGTPYYMSP ELCQGVKYNF KSDIWAVGCV 240
IFELLTLKRT FDATNPLNLC VKIVQGIRAM EVDSSQYSLE LIQLVHACLD QDPEQRPAAD 300
ALLDLPLLRT RRREMEEKVT LLNAPTKRPR SSTVTEAPIA VVTSRTSEVY VWGGGKSTPQ 360
KLDVIKSGCS ARQVCAGNTH FAVVTVEKEL YTWVNMQGGT KLHGQLGHGD KASYRQPKHV 420
EKLQGKAIHQ VSCGDDFTVC VTDEGQLYAF GSDYYGCMGV DKVSGPEVLE PMQLNFFLSN 480
PVEQVSCGDN HVVVLTRNKE VYSWGCGEYG RLGLDSEEDY YTPQRVDVPK ALIIVAVQCG 540
CDGTFLLTQS GKVLACGLNE FNKLGLNQCM SGIINHEAYH EVPYTTSFTL AKQLSFYKIR 600
TIAPGKTHTA AIDERGRLLT FGCNKCGQLG VGNYKKRLGI NLLGGPLGGK QVIRVSCGDE 660
FTIAATDDNH IFAWGNGGNG RLAMTPTERP HGSDICTSWP RPIFGSLHHV PDLSCRGWHT 720
ILIVEKVLNS KTIRSNSSGL SIGTVVQSSS PGGGIGGGGG GGGGGGGEEE DSQQESETPD 780
PSGGFRGTME ADRGMEGLIS PTEAVGNSCG ASSSCPGWLR KELENAEFIP MPDSPAPLSA 840
AFSQSEKDTL PYEELQGLKV ASEVPPEPQR AAGAWPPRLD PAVPCVGKAL TSAACACSAL 900
QVEVDRLQAL VLKCLEEQQK LQQENLQMFT QLQKLNKKLE GGQQVGMHSR GTQTAKEEME 960
MDPKPDLDSE SWCLLGTDSC RPSL 984 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |