CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038181
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase NEDD4-like 
Protein Synonyms/Alias
  
Gene Name
 Nedd4l 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
25ESRILRVKVVSGIDLubiquitination[1]
463SAPLEGAKDSPIRRAubiquitination[1]
540FPVHMRSKASLNPNDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ligase; Reference proteome; Repeat; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 976 AA 
Protein Sequence
MATGLGEPVY GLSEEEGESR ILRVKVVSGI DLAKKDIFGA SDPYVKLSLY VADENRELAL 60
VQTKTIKKTL NPKWNEEFYF RVNPSNHRLL FEVFDENRLT RDDFLGQVDV PLSHLPTEDP 120
TMERPYTFKD FLLRPRSHKS RVKGFLRLKM AYMPKNGGQD EENSEQRDDM EHGWEVVDSN 180
DSASQHQEEL PPPPLPPGWE EKVDNLGRTY YVNHNNRSTQ WHRPSLMDVS SESDNNIRQI 240
NQEAAHRRFR SRRHISEDLE PEASEGGGEG PEPWETISEE MNMAGDSLSL ALPPPPASPV 300
SRTSPQELSE EVSRRLQITP DSNGEQFSSL IQREPSSRLR SCSVTDTVAE QAHLPPPSTP 360
TRRARSSTVT GGEESTPSVA YVHTTPGLPS GWEERKDAKG RTYYVNHNNR TTTWTRPIMQ 420
LAEDGASGSA TNSNNHLVEP QIRRPRSLSS PTVTLSAPLE GAKDSPIRRA VKDTLSNPQS 480
PQPSPYNSPK PQHKVTQSFL PPGWEMRIAP NGRPFFIDHN TKTTTWEDPR LKFPVHMRSK 540
ASLNPNDLGP LPPGWEERIH LDGRTFYIDH NSKITQWEDP RLQNPAITGP AVPYSREFKQ 600
KYDYFRKKLK KPADIPNRFE MKLHRNNIFE ESYRRIMSVK RPDVLKARLW IEFESEKGLD 660
YGGVAREWFF LLSKEMFNPY YGLFEYSATD NYTLQINPNS GLCNEDHLSY FTFIGRVAGL 720
AVFHGKLLDG FFIRPFYKMM LGKQITLNDM ESVDSEYYNS LKWILENDPT ELDLMFCIDE 780
ENFGQTYQVD LKPNGSEIMV TNENKREYID LVIQWRFVNR VQKQMNAFLE GFTELLPIDL 840
IKIFDENELE LLMCGLGDVD VNDWRQHSIY KNGYCPNHPV IQWFWKAVLL MDAEKRIRLL 900
QFVTGTSRVP MNGFAELYGS NGPQLFTIEQ WGSPEKLPRA HTCFNRLDLP PYETFEDLRE 960
KLLMAVENAQ GFEGVD 976 
Gene Ontology
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0019871; F:sodium channel inhibitor activity; IDA:MGI.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.
 GO:0010766; P:negative regulation of sodium ion transport; IDA:MGI.
 GO:0003085; P:negative regulation of systemic arterial blood pressure; IMP:MGI.
 GO:2001259; P:positive regulation of cation channel activity; IGI:MGI.
 GO:0010765; P:positive regulation of sodium ion transport; IGI:MGI.
 GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
 GO:0042391; P:regulation of membrane potential; IEA:Compara.
 GO:1901016; P:regulation of potassium ion transmembrane transporter activity; IEA:Compara.
 GO:2000810; P:regulation of tight junction assembly; IDA:MGI.
 GO:0010038; P:response to metal ion; IEA:Compara.
 GO:0009651; P:response to salt stress; IMP:MGI.
 GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IDA:MGI. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR020477; C2_dom.
 IPR018029; C2_membr_targeting.
 IPR024928; E3_ub_ligase_SMURF1.
 IPR000569; HECT.
 IPR001202; WW_dom. 
Pfam
 PF00168; C2
 PF00632; HECT
 PF00397; WW 
SMART
 SM00239; C2
 SM00119; HECTc
 SM00456; WW 
PROSITE
 PS50004; C2
 PS50237; HECT
 PS01159; WW_DOMAIN_1
 PS50020; WW_DOMAIN_2 
PRINTS
 PR00360; C2DOMAIN.