UniProt Accession

 NRCAM_MOUSE; Q810U4; Q80U33; Q8BLG8; Q8BX92; Q8BYJ8 

Genbank Protein ID

 AJ543321; AK122252; AK039322; AK048567; AK045259 

Genbank Nucleotide ID

 CAD65848.1; BAC65534.1; BAC30318.1; BAC33377.1; BAC32284.1 

Protein Name

 Neuronal cell adhesion molecule 

Protein Synonyms/Alias

 Nr-CAM; Neuronal surface protein Bravo; mBravo; NgCAM-related cell adhesion molecule; Ng-CAM-related 

Gene Name

 Nrcam 

Gene Synonyms/Alias

 Kiaa0343 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
1168	DPEIQPMKEDDGTFG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier. 

Sequence Annotation

 DOMAIN 40 128 Ig-like C2-type 1.
 DOMAIN 135 229 Ig-like C2-type 2.
 DOMAIN 261 350 Ig-like C2-type 3.
 DOMAIN 355 442 Ig-like C2-type 4.
 DOMAIN 448 535 Ig-like C2-type 5.
 DOMAIN 539 626 Ig-like C2-type 6.
 DOMAIN 641 733 Fibronectin type-III 1.
 DOMAIN 740 834 Fibronectin type-III 2.
 DOMAIN 839 940 Fibronectin type-III 3.
 DOMAIN 946 1040 Fibronectin type-III 4.
 MOD_RES 421 421 Phosphoserine.
 MOD_RES 1178 1178 Phosphoserine.
 MOD_RES 1223 1223 Phosphoserine (By similarity).
 MOD_RES 1247 1247 Phosphoserine.
 CARBOHYD 77 77 N-linked (GlcNAc...) (Potential).
 CARBOHYD 217 217 N-linked (GlcNAc...) (Potential).
 CARBOHYD 239 239 N-linked (GlcNAc...) (Potential).
 CARBOHYD 245 245 N-linked (GlcNAc...) (Potential).
 CARBOHYD 270 270 N-linked (GlcNAc...) (Potential).
 CARBOHYD 308 308 N-linked (GlcNAc...) (Potential).
 CARBOHYD 371 371 N-linked (GlcNAc...) (Potential).
 CARBOHYD 427 427 N-linked (GlcNAc...) (Potential).
 CARBOHYD 501 501 N-linked (GlcNAc...) (Potential).
 CARBOHYD 613 613 N-linked (GlcNAc...) (Potential).
 CARBOHYD 710 710 N-linked (GlcNAc...) (Potential).
 CARBOHYD 796 796 N-linked (GlcNAc...) (Potential).
 CARBOHYD 852 852 N-linked (GlcNAc...) (Potential).
 CARBOHYD 987 987 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1003 1003 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1013 1013 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1067 1067 N-linked (GlcNAc...) (Potential).
 DISULFID 62 117 Potential.
 DISULFID 161 212 Potential.
 DISULFID 286 334 Potential.
 DISULFID 376 426 Potential.
 DISULFID 470 519 Potential.
 DISULFID 561 610 Potential.  

Keyword

 Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1256 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0045202; C:synapse; IDA:MGI.
 GO:0030506; F:ankyrin binding; ISS:UniProtKB.
 GO:0086080; F:protein binding involved in heterotypic cell-cell adhesion; IGI:MGI.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0007417; P:central nervous system development; IDA:UniProtKB.
 GO:0045162; P:clustering of voltage-gated sodium channels; ISS:UniProtKB.
 GO:0019227; P:neuronal action potential propagation; IMP:MGI.
 GO:0008104; P:protein localization; IDA:MGI.
 GO:0010975; P:regulation of neuron projection development; IMP:MGI.
 GO:0031290; P:retinal ganglion cell axon guidance; IMP:MGI. 

Interpro

 IPR026966; Fibronectin_III_C.
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2. 

Pfam

 PF13882; Bravo_FIGEY
 PF00041; fn3
 PF07679; I-set 

SMART

 SM00060; FN3
 SM00409; IG
 SM00408; IGc2 

PROSITE

 PS50853; FN3
 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS