CPLM-034497

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-034497

UniProt Accession

D3Z700_MOUSE; D3Z700

Genbank Protein ID

Genbank Nucleotide ID

Protein Name

TFIIH basal transcription factor complex helicase XPD subunit

Protein Synonyms/Alias

Gene Name

Ercc2

Gene Synonyms/Alias

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
255	DQVAISSKFETREDI	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Sequence Annotation

Keyword

ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

508 AA

Protein Sequence

MKTLDRCQSN LDTLQKTVLR IKETDEQRLR DEYRRLVEGL REASVARETD AHLANPVLPD 60
EVLQEAVPGS IRTAEHFLGF LRRLLEYVKW RLRVQHVVQE SPPAFLSGLA QRVCIQRKPL 120
RFCAERLRSL LHTLEIADLA DFSPLTLLAN FATLVSTYAK GFTIIIEPFD DRTPTIANPV 180
LHFSCMDASL AIKPVFERFQ SVIITSGTLS PLDIYPKILD FHPVTMATFT MTLARVCLCP 240
MIIGRGNDQV AISSKFETRE DIAVIRNYGN LLLEMSAVVP DGIVAFFTSY QYMESTVASW 300
YEQGILENIQ RNKLLFIETQ DGAETSVALE KYQEACENGR GAILLSVARG KVSEGIDFVH 360
HYGRAVIMFG VPYVYTQSRI LKARLEYLRD QFQIRENDFL TFDAMRHAAQ CVGRAIRGKT 420
DYGLMVFADK RFARADKRGK LPRWIQEHLT DSNLNLTVDE GVQVAKYFLR QMAQPFHRED 480
QLGLSLLSLE QLQSEETLQR IEQIAQQL 508

Gene Ontology

GO:0005634; C:nucleus; IDA:MGI.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro.
GO:0003677; F:DNA binding; IEA:InterPro.
GO:0007568; P:aging; IMP:MGI.
GO:0006915; P:apoptotic process; IMP:MGI.
GO:0030282; P:bone mineralization; IMP:MGI.
GO:0008283; P:cell proliferation; IMP:MGI.
GO:0032289; P:central nervous system myelin formation; IMP:MGI.
GO:0040016; P:embryonic cleavage; IMP:MGI.
GO:0043249; P:erythrocyte maturation; IMP:MGI.
GO:0030198; P:extracellular matrix organization; IMP:MGI.
GO:0035315; P:hair cell differentiation; IMP:MGI.
GO:0048820; P:hair follicle maturation; IMP:MGI.
GO:0060218; P:hematopoietic stem cell differentiation; IMP:MGI.
GO:0001701; P:in utero embryonic development; IMP:MGI.
GO:0035264; P:multicellular organism growth; IMP:MGI.
GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
GO:0006289; P:nucleotide-excision repair; IMP:MGI.
GO:0043388; P:positive regulation of DNA binding; IMP:MGI.
GO:0009791; P:post-embryonic development; IMP:MGI.
GO:0006979; P:response to oxidative stress; IMP:MGI.
GO:0043588; P:skin development; IMP:MGI.
GO:0021510; P:spinal cord development; IMP:MGI.
GO:0009650; P:UV protection; IMP:MGI.

Interpro

IPR006555; ATP-dep_Helicase_C.
IPR013020; DNA_helicase_DNA-repair_Rad3.
IPR010643; DUF1227.
IPR001945; XPGD_DNA_repair.

Pfam

PF06777; DUF1227
PF13307; Helicase_C_2

SMART

SM00491; HELICc2

PROSITE

PRINTS

PR00852; XRODRMPGMNTD.