UniProt Accession

 PGM2_MOUSE; Q7TSV4; Q8K0P7; Q9CRS8 

Genbank Protein ID

 BC030869; BC052762; AK014332 

Genbank Nucleotide ID

 AAH30869.1; AAH52762.1; BAB29278.1 

Protein Name

 Phosphoglucomutase-2 

Protein Synonyms/Alias

 PGM 2; Glucose phosphomutase 2; Phosphodeoxyribomutase; Phosphoglucomutase-1; Phosphopentomutase 

Gene Name

 Pgm2 

Gene Synonyms/Alias

 Pgm1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
99	GFCRYLEKQFSDLKQ	acetylation	[1, 2]
105	EKQFSDLKQRGVVIS	acetylation	[1]
324	LADKIKAKIVLANDP	ubiquitination	[3]
520	NYPKMCGKFEISAIR	acetylation	[1]
575	SGTEPKIKYYAELCA	acetylation	[1]
593	NSDPEHLKKELDELV	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity (By similarity). 

Sequence Annotation

 ACT_SITE 173 173 Phosphoserine intermediate (By
 METAL 173 173 Magnesium; via phosphate group (By
 METAL 330 330 Magnesium (By similarity).
 METAL 332 332 Magnesium (By similarity).
 METAL 334 334 Magnesium (By similarity).
 MOD_RES 173 173 Phosphoserine.  

Keyword

 Carbohydrate metabolism; Complete proteome; Cytoplasm; Glucose metabolism; Isomerase; Magnesium; Metal-binding; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 620 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0004614; F:phosphoglucomutase activity; IDA:MGI.
 GO:0008973; F:phosphopentomutase activity; IEA:EC.
 GO:0016052; P:carbohydrate catabolic process; IBA:RefGenome.
 GO:0046386; P:deoxyribose phosphate catabolic process; IEA:UniProtKB-UniPathway.
 GO:0006006; P:glucose metabolic process; IDA:MGI. 

Interpro

 IPR005844; A-D-PHexomutase_a/b/a-I.
 IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
 IPR005845; A-D-PHexomutase_a/b/a-II.
 IPR005846; A-D-PHexomutase_a/b/a-III.
 IPR005843; A-D-PHexomutase_C.
 IPR016066; A-D-PHexomutase_CS. 

Pfam

 PF02878; PGM_PMM_I
 PF02879; PGM_PMM_II
 PF02880; PGM_PMM_III
 PF00408; PGM_PMM_IV 

SMART

  

PROSITE

 PS00710; PGM_PMM 

PRINTS