CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023500
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kunitz-type protease inhibitor 2 
Protein Synonyms/Alias
 Hepatocyte growth factor activator inhibitor type 2; HAI-2 
Gene Name
 Spint2 
Gene Synonyms/Alias
 Hai2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
242VWSTADDKEQLVKNTubiquitination[1]
247DDKEQLVKNTCVL**ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Inhibitor of HGF activator. 
Sequence Annotation
 DOMAIN 38 88 BPTI/Kunitz inhibitor 1.
 DOMAIN 133 183 BPTI/Kunitz inhibitor 2.
 CARBOHYD 57 57 N-linked (GlcNAc...) (Potential).
 CARBOHYD 94 94 N-linked (GlcNAc...) (Potential).
 DISULFID 38 88 By similarity.
 DISULFID 47 71 By similarity.
 DISULFID 63 84 By similarity.
 DISULFID 133 183 By similarity.
 DISULFID 142 166 By similarity.
 DISULFID 158 179 By similarity.  
Keyword
 Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Protease inhibitor; Reference proteome; Repeat; Serine protease inhibitor; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 252 AA 
Protein Sequence
MAQLCELRRG RALLALVASL LLSGAQVASR ELDVHESCGV SKVVGKCRAS IPRWWYNITD 60
GSCQPFVYGG CEGNGNNYQS KEECLDKCAG VTENTTDDMA RNRNGADSSV LSVPRKQSAE 120
DLSAEIFNYE EYCVPKAVTG PCRAAFPRWY YDTEKNSCIS FIYGGCRGNK NSYLSQEACM 180
QHCSGKQMHP FLTPGLKAVI LVGLFLMVLI LLLGTSMVCL IRVVRRKQER ALRTVWSTAD 240
DKEQLVKNTC VL 252 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW. 
Interpro
 IPR002223; Prot_inh_Kunz-m.
 IPR020901; Prtase_inh_Kunz-CS. 
Pfam
 PF00014; Kunitz_BPTI 
SMART
 SM00131; KU 
PROSITE
 PS00280; BPTI_KUNITZ_1
 PS50279; BPTI_KUNITZ_2 
PRINTS
 PR00759; BASICPTASE.