Tag | Content |
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CPLM ID | CPLM-023500 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Kunitz-type protease inhibitor 2 |
Protein Synonyms/Alias | Hepatocyte growth factor activator inhibitor type 2; HAI-2 |
Gene Name | Spint2 |
Gene Synonyms/Alias | Hai2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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242 | VWSTADDKEQLVKNT | ubiquitination | [1] | 247 | DDKEQLVKNTCVL** | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Inhibitor of HGF activator. |
Sequence Annotation | DOMAIN 38 88 BPTI/Kunitz inhibitor 1. DOMAIN 133 183 BPTI/Kunitz inhibitor 2. CARBOHYD 57 57 N-linked (GlcNAc...) (Potential). CARBOHYD 94 94 N-linked (GlcNAc...) (Potential). DISULFID 38 88 By similarity. DISULFID 47 71 By similarity. DISULFID 63 84 By similarity. DISULFID 133 183 By similarity. DISULFID 142 166 By similarity. DISULFID 158 179 By similarity. |
Keyword | Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Protease inhibitor; Reference proteome; Repeat; Serine protease inhibitor; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 252 AA |
Protein Sequence | MAQLCELRRG RALLALVASL LLSGAQVASR ELDVHESCGV SKVVGKCRAS IPRWWYNITD 60 GSCQPFVYGG CEGNGNNYQS KEECLDKCAG VTENTTDDMA RNRNGADSSV LSVPRKQSAE 120 DLSAEIFNYE EYCVPKAVTG PCRAAFPRWY YDTEKNSCIS FIYGGCRGNK NSYLSQEACM 180 QHCSGKQMHP FLTPGLKAVI LVGLFLMVLI LLLGTSMVCL IRVVRRKQER ALRTVWSTAD 240 DKEQLVKNTC VL 252 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW. |
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PRINTS | |