| Tag | Content |
|---|
| CPLM ID | CPLM-011739 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Xaa-Pro dipeptidase |
Protein Synonyms/Alias | X-Pro dipeptidase; Imidodipeptidase; Peptidase 4; Peptidase D; Proline dipeptidase; Prolidase |
Gene Name | Pepd |
Gene Synonyms/Alias | Pep4 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 17 | SLGNETLKVPLALFA | ubiquitination | [1] | | 110 | SYATWMGKIHSKEYF | ubiquitination | [1] | | 120 | SKEYFKEKYAVDDVQ | ubiquitination | [1] | | 303 | GKFTEDQKAIYEAVL | ubiquitination | [1] | | 484 | ACMAGCDKASVPFSG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because of the high level of iminoacids in collagen. |
Sequence Annotation | METAL 276 276 Manganese 1 (By similarity).
METAL 287 287 Manganese 1 (By similarity).
METAL 287 287 Manganese 2 (By similarity).
METAL 370 370 Manganese 2 (By similarity).
METAL 412 412 Manganese 2 (By similarity).
METAL 452 452 Manganese 1 (By similarity).
METAL 452 452 Manganese 2 (By similarity).
MOD_RES 2 2 N-acetylalanine (Potential). |
Keyword | Acetylation; Collagen degradation; Complete proteome; Dipeptidase; Hydrolase; Manganese; Metal-binding; Metalloprotease; Protease; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 493 AA |
Protein Sequence | MASTVRPSFS LGNETLKVPL ALFALNRQRL CERLRKNGAV QAASAVVLQG GEEMQRYCTD 60
TSIIFRQESF FHWAFGVVES GCYGVIDVDT GKSTLFVPRL PDSYATWMGK IHSKEYFKEK 120
YAVDDVQYTD EIASVLTSRN PSVLLTLRGV NTDSGSVCRE ASFEGISKFN VNNTILHPEI 180
VECRVFKTDM ELEVLRYTNR ISSEAHREVM KAVKVGMKEY EMESLFQHYC YSRGGMRHTS 240
YTCICCSGEN AAVLHYGHAG APNDRTIKDG DICLFDMGGE YYCFASDITC SFPANGKFTE 300
DQKAIYEAVL RSCRTVMSTM KPGVWWPDMH RLADRIHLEE LARIGLLSGS VDAMLQVHLG 360
AVFMPHGLGH FLGLDVHDVG GYPEGVERID EPGLRSLRTA RHLEPGMVLT VEPGIYFIDH 420
LLDQALADPA QACFFNQEVL QRFRNFGGVR IEEDVVVTDS GMELLTCVPR TVEEIEACMA 480
GCDKASVPFS GQK 493 |
Gene Ontology | GO:0004177; F:aminopeptidase activity; IEA:InterPro. GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW. GO:0030145; F:manganese ion binding; IEA:InterPro. GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW. GO:0008233; F:peptidase activity; IDA:MGI. GO:0009987; P:cellular process; IEA:InterPro. GO:0030574; P:collagen catabolic process; IEA:UniProtKB-KW. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |