UniProt Accession

 MTLD_ECOLI; P09424; Q2M7R3 

Genbank Protein ID

 X51359; U00039; U00096; AP009048; X06794; U03845 

Genbank Nucleotide ID

 CAA35744.1; AAB18577.1; AAC76624.1; BAE77693.1; CAA29954.1; AAA92661.1 

Protein Name

 Mannitol-1-phosphate 5-dehydrogenase 

Protein Synonyms/Alias

  

Gene Name

 mtlD 

Gene Synonyms/Alias

 b3600; JW3574 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
212	LMAFVERKLFTLNTG	acetylation	[1]
243	RDAILDEKIRAVVKG	acetylation	[1]
261	ESGAVLIKRYGFDAD	acetylation	[1]
269	RYGFDADKHAAYIQK	acetylation	[1, 2]
276	KHAAYIQKILGRFEN	acetylation	[1]
287	RFENPYLKDDVERVG	acetylation	[1]
309	SAGDRLIKPLLGTLE	acetylation	[1, 3]
379	SEAVTAYKAMQ****	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli.
 Zhang J, Sprung R, Pei J, Tan X, Kim S, Zhu H, Liu CF, Grishin NV, Zhao Y.
 Mol Cell Proteomics. 2009 Feb;8(2):215-25. [PMID: 18723842]
 [3] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

  

Sequence Annotation

 NP_BIND 3 14 NAD (By similarity).
 MOD_RES 269 269 N6-acetyllysine.  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; NAD; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 382 AA 

Protein Sequence

Gene Ontology

 GO:0050662; F:coenzyme binding; IEA:InterPro.
 GO:0008926; F:mannitol-1-phosphate 5-dehydrogenase activity; IEA:HAMAP.
 GO:0019594; P:mannitol metabolic process; IEA:InterPro. 

Interpro

 IPR008927; 6-PGluconate_DH_C-like.
 IPR013328; DH_multihelical.
 IPR023028; Mannitol_1_phos_5_DH.
 IPR000669; Mannitol_DH.
 IPR013118; Mannitol_DH_C.
 IPR023027; Mannitol_DH_CS.
 IPR013131; Mannitol_DH_N.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF01232; Mannitol_dh
 PF08125; Mannitol_dh_C 

SMART

  

PROSITE

 PS00974; MANNITOL_DHGENASE 

PRINTS

 PR00084; MTLDHDRGNASE.