CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006465
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ras-related protein Rab-8A 
Protein Synonyms/Alias
  
Gene Name
 Rab8a 
Gene Synonyms/Alias
 Rab8 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
3*****MAKTYDYLFKacetylation[1]
55RTIELDGKRIKLQIWacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis (By similarity). 
Sequence Annotation
 NP_BIND 15 22 GTP (By similarity).
 NP_BIND 63 67 GTP (By similarity).
 NP_BIND 121 124 GTP (By similarity).
 MOTIF 37 45 Effector region (By similarity).
 MOD_RES 181 181 Phosphoserine (By similarity).
 MOD_RES 185 185 Phosphoserine (By similarity).
 MOD_RES 204 204 Cysteine methyl ester (Potential).
 LIPID 204 204 S-geranylgeranyl cysteine (By  
Keyword
 Cell membrane; Cell projection; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 207 AA 
Protein Sequence
MAKTYDYLFK LLLIGDSGVG KTCVLFRFSE DAFNSTFIST IGIDFKIRTI ELDGKRIKLQ 60
IWDTAGQERF RTITTAYYRG AMGIMLVYDI TNEKSFDNIR NWIRNIEEHA SADVEKMILG 120
NKCDVNDKRQ VSKERGEKLA LDYGIKFMET SAKANINVEN AFFTLARDIK AKMDKKLEGN 180
SPQGSSHGVK ITVEQQKRTS FFRCSLL 207 
Gene Ontology
 GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005932; C:microtubule basal body; IEA:Compara.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0031513; C:nonmotile primary cilium; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0045335; C:phagocytic vesicle; ISS:UniProtKB.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0014069; C:postsynaptic density; IDA:RGD.
 GO:0055037; C:recycling endosome; IEA:Compara.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; ISS:UniProtKB.
 GO:0007409; P:axonogenesis; IMP:UniProtKB.
 GO:0042384; P:cilium assembly; ISS:UniProtKB.
 GO:0048210; P:Golgi vesicle fusion to target membrane; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IDA:RGD.
 GO:0051223; P:regulation of protein transport; IDA:RGD.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO:0006904; P:vesicle docking involved in exocytosis; IEA:Compara. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 
Pfam
 PF00071; Ras 
SMART
 SM00175; RAB 
PROSITE
 PS51419; RAB 
PRINTS
 PR00449; RASTRNSFRMNG.