UniProt Accession

 B3KWN8_HUMAN; B3KWN8 

Genbank Protein ID

 AC006559; AK125461 

Genbank Nucleotide ID

 BAG54200.1 

Protein Name

 Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 

Protein Synonyms/Alias

 cDNA FLJ43472 fis, clone OCBBF2037638 

Gene Name

 PYROXD1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
17	KVIESGVKQLKSEEH	ubiquitination	[1]
37	DGNQHVYKKLCLCAG	ubiquitination	[1]
38	GNQHVYKKLCLCAGA	ubiquitination	[1]
46	LCLCAGAKPKLICEG	ubiquitination	[1]
71	DSAQEFQKQLTKAKR	ubiquitination	[1, 2, 3]
107	VIWAIKDKAIGNTFF	ubiquitination	[1]
125	AAEFLTSKLIAEKSE	ubiquitination	[1]
130	TSKLIAEKSEAKIAH	ubiquitination	[1]
175	WHEGLNLKGTKEFSH	ubiquitination	[1]
194	ETMCEVKKIYLQDEF	ubiquitination	[1]
207	EFRILKKKSFTFPRD	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 429 AA 

Protein Sequence

Gene Ontology

 GO:0016491; F:oxidoreductase activity; IEA:InterPro. 

Interpro

 IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD. 

Pfam

 PF07992; Pyr_redox_2 

SMART

  

PROSITE

  

PRINTS