| Tag | Content |
|---|
| CPLM ID | CPLM-014543 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ras GTPase-activating protein 2 |
Protein Synonyms/Alias | GAP1m |
Gene Name | Rasa2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 582 | ERYFTDVKKFLDEIS | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4) and phospholipids. |
Sequence Annotation | DOMAIN 24 121 C2 1.
DOMAIN 157 272 C2 2.
DOMAIN 355 549 Ras-GAP.
DOMAIN 603 704 PH.
ZN_FING 706 742 Btk-type. |
Keyword | Cell membrane; Complete proteome; GTPase activation; Membrane; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 847 AA |
Protein Sequence | MAAAAPAAAA LTEAPAVPGT AEPETGDEDS REVRVLQSLR GRIYEAKNLL PYLGPNKMRD 60
CFCTINLDQE EVYRTQVVEK SLSPYFSEEF YFEIPRTFQY LSFYVYDKNV LQRDLRIGKV 120
AIKKEDLCSH SGKETWFSLQ PIDSNSEVQG KVHLELKLNE LITENGTVCQ QLVVHIKACH 180
GLPLINGQSC DPYATVSLVG PSRNDQKKTK VKKKTSNPQF NEVFYFEVTR SSSYTRKSQF 240
QVEEEDIEKL EIRIDLWNNE NLVQDVFLGE IKVPVNVLRN DSSHQAWYLL QPRDNGNKSS 300
KPDDLGSLLL TLCYTEDYVL PSEYYGPLKA LLLKSPDVQP VSASAAYILG EICRDQKDAV 360
LPLVRLLLHH NKLVPFITAV ADLDLKDTQD ANAIFRGNSL ATQCLTEMMK IVGGHYLKVT 420
LKPVLDEICE SSKSCEIDPV KLKEGDNVES NKENLYYYVD KVFSAIVGSS VSCPTVMCDI 480
FYSLRQMAAK RFPNNPHVQY SAVSSFVFLR FFAVAILSPH AFHLRPHYPD TQTVRTLTLI 540
SKTIQIIGNW GCQSRRKSRF KKSVMCEFLK MFQEERYFTD VKKFLDEISS TETKESSGTS 600
EPVHLKEGEM YKRAQGRTRI GKKNFKKRWF CLTSKELTYH KQQGKDAIYT IPVKNILAVE 660
KLEESSFNKK NMFQVIHTEK TLYIQANNCV EANEWIDMLC RVSRCNHNRL SSFHPSAYLN 720
GNWLCCQETS EGTPGCKPCT AGIPADIQID IDEDRETERI YSVFTLSLLK LQKMEEACGS 780
IAVYQGPQKE PGYSKFTIED SVATFKTIQQ IKSTIEKLDE PHEKYRKKRS SSAKYGSKEN 840
PIVGKIS 847 |
Gene Ontology | GO:0005737; C:cytoplasm; IBA:RefGenome. GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara. GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005099; F:Ras GTPase activator activity; IDA:RGD. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |