| Tag | Content |
|---|
| CPLM ID | CPLM-013048 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Interferon-stimulated 20 kDa exonuclease-like 2 |
Protein Synonyms/Alias | |
Gene Name | Isg20l2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 23 | KAFGGNAKHQRFVKK | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA (By similarity). Displays a strong specificity for a 3'-end containing a free hydroxyl group (By similarity). |
Sequence Annotation | DOMAIN 194 368 Exonuclease. |
Keyword | Complete proteome; Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome; Ribosome biogenesis. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 368 AA |
Protein Sequence | MSTILLNLDF GQPSKKAFGG NAKHQRFVKK RRFLEQKGFL NKKNQPPNKV SKLNSEPPKK 60
GETSRVDGIL KILPCPKKKE AAASKRDSER SKDKKAPLSW LTPAPSKKTA SVVSKIDLLG 120
EFQSALPKTK STQKKGSKKK SLKKKIATEN STQAQSKDKG SKKKPLKKNA VPNSTQARSE 180
DKCPTVPQNL PGKMVAIDCE MVGTGPKGRV SSLARCSIVN YNGDVLYDEY VLPPCYIVNY 240
RTRWSGIRKC HMVNATPFKT ARSQILKILS GKVVIGHAIH NDYKALQYFH PKSLTRDTSR 300
IPLLNRKADC PENVTLSLKH LTKKLLSRDI QVGNTGHSSV EDAQATMELY KLVEVEWEQH 360
LAQNPPEN 368 |
Gene Ontology | GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. GO:0003676; F:nucleic acid binding; IEA:InterPro. GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC. GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |