| Tag | Content |
|---|
| CPLM ID | CPLM-021626 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein 287 |
Protein Synonyms/Alias | Zinc finger protein with KRAB and SCAN domains 13 |
Gene Name | ZNF287 |
Gene Synonyms/Alias | ZKSCAN13 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 290 | DERGFSLKSVLSQEY | ubiquitination | [1] | | 396 | YECEECGKEFRHISS | ubiquitination | [1] | | 471 | QRTHTGEKPYKCLEC | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May be involved in transcriptional regulation. |
Sequence Annotation | DOMAIN 42 124 SCAN box.
DOMAIN 163 231 KRAB.
ZN_FING 361 383 C2H2-type 1.
ZN_FING 389 411 C2H2-type 2.
ZN_FING 417 439 C2H2-type 3.
ZN_FING 445 467 C2H2-type 4.
ZN_FING 473 495 C2H2-type 5.
ZN_FING 501 523 C2H2-type 6.
ZN_FING 529 551 C2H2-type 7.
ZN_FING 557 579 C2H2-type 8.
ZN_FING 585 607 C2H2-type 9.
ZN_FING 613 635 C2H2-type 10.
ZN_FING 641 663 C2H2-type 11.
ZN_FING 669 691 C2H2-type 12.
ZN_FING 697 719 C2H2-type 13.
ZN_FING 725 747 C2H2-type 14. |
Keyword | Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 754 AA |
Protein Sequence | MNSSSRSQIL LRWKSDKAQS GPYNVEKEIL TSRFLRDTET CRQNFRNFPY PDLAGPRKAL 60
SQLRELCLKW LRPEIHSKEQ ILELLVLEQF LTILPGEVRT WVKSQYPESS EEAVTLVEDL 120
TQILEEEAPQ NSTLSQDTPE EDPRGKHAFQ TGWLNDLVTK ESMTFKDVAV DITQEDWELM 180
RPVQKELYKT VTLQNYWNMV SLGLTVYRPT VIPILEEPWM VIKEILEGPS PEWETKAQAC 240
TPVEDMSKLT KEETHTIKLE DSYDYDDRLE RRGKGGFWKI HTDERGFSLK SVLSQEYDPT 300
EECLSKYDIY RNNFEKHSNL IVQFDTQLDN KTSVYNEGRA TFNHVSYGIV HRKILPGEKP 360
YKCNVCGKKF RKYPSLLKHQ STHAKEKSYE CEECGKEFRH ISSLIAHQRM HTGEKPYECH 420
QCGKAFSQRA HLTIHQRIHT GEKPYKCDDC GKDFSQRAHL TIHQRTHTGE KPYKCLECGK 480
TFSHSSSLIN HQRVHTGEKP YICNECGKTF SQSTHLLQHQ KIHTGKKPYK CNECWKVFSQ 540
STYLIRHQRI HSGEKCYKCN ECGKAFAHSS TLIQHQTTHT GEKSYICNIC GKAFSQSANL 600
TQHHRTHTGE KPYKCSVCGK AFSQSVHLTQ HQRIHNGEKP FKCNICGKAY RQGANLTQHQ 660
RIHTGEKPYK CNECGKAFIY SSSLNQHQRT HTGERPYKCN ECDKDFSQRT CLIQHQRIHT 720
GEKPYACRIC GKTFTQSTNL IQHQRVHTGA KHRN 754 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara. GO:0042035; P:regulation of cytokine biosynthetic process; IEA:Compara. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0016032; P:viral reproduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |