CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019838
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tetratricopeptide repeat protein 30A1 
Protein Synonyms/Alias
 TPR repeat protein 30A1 
Gene Name
 Ttc30a1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
122LRLQAAIKYSEGDLPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Required for polyglutamylation of axonemal tubulin (By similarity). Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity). 
Sequence Annotation
 REPEAT 11 44 TPR 1.
 REPEAT 45 78 TPR 2.
 REPEAT 153 186 TPR 3.
 REPEAT 188 220 TPR 4.
 REPEAT 393 423 TPR 5.
 REPEAT 424 456 TPR 6.
 REPEAT 458 491 TPR 7.
 REPEAT 543 576 TPR 8.  
Keyword
 Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 664 AA 
Protein Sequence
MAWQSSSKVP DGEFTAVVYR LIRDSRYSEA VQLLSAELQR SSRSRAGLSL LAYCYYRLQE 60
FELAAECYEQ LSQMHPELEQ YRLYQAQALY KACLYPEATR VTFLLDNPAY QTRVLRLQAA 120
IKYSEGDLPG ARSLVEQLLS GEAGEDSGGE NDPDGLVNMG CLLYKEGHYE AACSKFLAAL 180
QASGYQPDLS YNLALAYYSS RQYAPALKHI ADIIERGIRQ HPELGVGMTT EGIDVRSVGN 240
TVVLHQTALI EAFNLKAAIE YQLRNFEVAQ ETLTDMPPRA EEELDPVTLH NQALMNMDAK 300
PTEGFEKLQF LLQQNPFPPE TFGNLLLLYC KYEYFDLAAD VLAENAHLTY KFLTPYLYDF 360
LDAMITCQTA PEEAFIKLDG LAGMLTEQLR RLTKQVQEAR HNRDDEIIKK AMNEYDETLE 420
KYIPVLMAQA KIYWNLENYP MVEKIFRKSV EFCNDHDVWK LNVAHVLFMQ ENKYKEAIGF 480
YEPIVKKNYD NILSVSAIVL ANLCVSYIMT SQNEEAEELM RKIEKEEEQL SYGDPDKKIY 540
HLCIVNLVIG TLYCAKGNYD FGISRVIKSL EPYHKKLGTD TWYYAKRCFL SLLENMSKHM 600
IVLCDGVVQE CVQFLEYCEL YGRNIPAVLE QPLEEERIHT GKNTVTYESR LLKALIYEVI 660
GWNM 664 
Gene Ontology
 GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
 GO:0030030; P:cell projection organization; IEA:UniProtKB-KW. 
Interpro
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 
Pfam
 PF07719; TPR_2 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS