UniProt Accession

 ARC1A_HUMAN; Q92747; A4D276; D6W5S1; Q7Z5U8; Q86WU5; Q8IXQ0 

Genbank Protein ID

 Y08999; CH236956; CH471091; CH471091; BC039594; BC047889; BC054027 

Genbank Nucleotide ID

 CAA70203.1; EAL23883.1; EAW76682.1; EAW76683.1; AAH39594.2; AAH47889.2; AAH54027.1 

Protein Name

 Actin-related protein 2/3 complex subunit 1A 

Protein Synonyms/Alias

 SOP2-like protein 

Gene Name

 ARPC1A 

Gene Synonyms/Alias

 SOP2L 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
63	TGIDWAPKSDRIVTC	ubiquitination	[1]
87	SQKDGVWKPTLVILR	ubiquitination	[1, 2]
103	NRAATFVKWSPLENK	ubiquitination	[3]
110	KWSPLENKFAVGSGA	ubiquitination	[3]
179	YIKEVDEKPASTPWG	ubiquitination	[3]
235	VSVADASKSVQVSTL	ubiquitination	[3]
290	VSKLDIPKQSIQRNM	ubiquitination	[1, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. 

Sequence Annotation

 REPEAT 6 45 WD 1.
 REPEAT 50 89 WD 2.
 REPEAT 140 179 WD 3.
 REPEAT 202 241 WD 4.
 REPEAT 244 284 WD 5.
 REPEAT 322 365 WD 6.  

Keyword

 Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 370 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; TAS:ProtInc.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0003779; F:actin binding; TAS:ProtInc.
 GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro. 

Interpro

 IPR017383; ARPC2/3_su1.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS