CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024102
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Red 
Protein Synonyms/Alias
 Cytokine IK; IK factor; Protein RER 
Gene Name
 Ik 
Gene Synonyms/Alias
 Red; Rer 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
137GPTAEADKSAAEKRRacetylation[1]
173LDFALLQKVRAEIASubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May bind to chromatin. 
Sequence Annotation
 REPEAT 342 343 1.
 REPEAT 344 345 2.
 REPEAT 346 347 3.
 REPEAT 348 349 4.
 REPEAT 350 351 5.
 REPEAT 352 353 6.
 REPEAT 354 355 7.
 REPEAT 356 357 8.
 REPEAT 358 359 9.
 REPEAT 360 361 10.
 REPEAT 362 363 11.
 REPEAT 364 365 12.
 REPEAT 366 367 13.
 REPEAT 368 369 14.
 REPEAT 370 371 15.
 REPEAT 372 373 16.
 REPEAT 374 375 17.
 REGION 342 375 17 X 2 AA tandem repeats of R-[ED].
 MOD_RES 98 98 N6-acetyllysine (By similarity).
 MOD_RES 460 460 Phosphoserine (By similarity).
 MOD_RES 485 485 Phosphothreonine (By similarity).  
Keyword
 Acetylation; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 557 AA 
Protein Sequence
MPERDSEPFS NPLAPDGHDV DDPHSFHQSK LTNEDFRKLL MTPRAAPTSA PPSKSRHHEM 60
PREYNEDEDP AARRRKKKSY YAKLRQQEIE RERELAEKYR DRAKERRDGV NKDYEETELI 120
STTANYRAVG PTAEADKSAA EKRRQLIQES KFLGGDMEHT HLVKGLDFAL LQKVRAEIAS 180
KEKEEEELME KPQKETKKDE DPENKIEFKT RLGRNVYRML FKSKSYERNE LFLPGRMAYV 240
VDLDDEYADT DIPTTLIRSK ADCPTMEAQT TLTTNDIVIS KLTQILSYLR QGTRNKKLKK 300
KDKGKLEEKK PPEADMNIFE DIGDYVPSTT KTPRDKERER YRERERDRER DRDRERDRER 360
DRERERERDR EREREEEKKR HSYFEKPKVD DEPMDVDKGP GSAKELIKSI NEKFAGSAGW 420
EGTESLKKPE DKKQLGDFFG MSNSYAECYP ATMDDMAVDS DEEVDYSKMD QGNKKGPLGR 480
WDFDTQEEYS EYMNNKEALP KAAFQYGIKM SEGRKTRRFK ETNDKAELDR QWKKISAIIE 540
KRKRMEADGV EVKRPKY 557 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR012492; RED_C.
 IPR012916; RED_N. 
Pfam
 PF07807; RED_C
 PF07808; RED_N 
SMART
  
PROSITE
  
PRINTS