CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009974
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phospholipase D1 
Protein Synonyms/Alias
 PLD 1; rPLD1; Choline phosphatase 1; Phosphatidylcholine-hydrolyzing phospholipase D1 
Gene Name
 Pld1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
189QLEDYLTKILKMPMYubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). 
Sequence Annotation
 DOMAIN 81 212 PX.
 DOMAIN 219 328 PH.
 DOMAIN 459 486 PLD phosphodiesterase 1.
 DOMAIN 891 918 PLD phosphodiesterase 2.
 REGION 463 928 Catalytic.
 MOD_RES 629 629 Phosphoserine (By similarity).
 LIPID 240 240 S-palmitoyl cysteine (Probable).
 LIPID 241 241 S-palmitoyl cysteine (Probable).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Endoplasmic reticulum; Endosome; Golgi apparatus; Hydrolase; Lipid degradation; Lipid metabolism; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1074 AA 
Protein Sequence
MSLRSEARVN TSTLQKIAAD MSNLIENLDT RELHFEGEEV EYDASPGDPT AQEACIPFSS 60
IYNTQGFKEP NIQIYLSGCP VKAQVLEVER FTSTSRMPSV NLYTIELTHG EFTWQVKRKF 120
KHFQEFHREL LKYKAFIRIP IPTKRHTFRR QNVKEEPREM PSLPRSSENA IQEEQFFGRR 180
KQLEDYLTKI LKMPMYRNYH ATTEFLDVSQ LSFIHDLGPK GLEGMIMKRS GGHRIPGVNC 240
CGHGRACYRW SKRWLIVKDS FLLYMKPDSG AIAFVLLVDK EFRIKVGKKE TETKYGLRID 300
NLSRTLILKC NSYRHARWWG GAIEEFIQKH GTDFLKDHRF GSYAAVHENI LAKWYVNAKG 360
YFEDIANAME GATEEIFITD WWLSPEIFLK RPVVEGNRWR LDCILKRKAQ QGVRIFIMLY 420
KEVELALGIN SEYTKRTLMR LHPNIKVMRH PDHVSSSVYL WAHHEKLVII DQSVAFVGGI 480
DLAYGRWDDN EHRLTDVGSV KRVTSGQSLG SLTAASVESM ESLSLKDKHQ SHKNEPVLKS 540
VNDTDMKLKG IGKSRKFSKF SLYRQLHRRN LHNSDSISSV DSASSYFNHY RSHQNLIHGI 600
KPHLKLFRPS SESEQGLTRH SADTGSIRSV QTGVGELHGE TRFWHGKDYC NFVFKDWVQL 660
DKPFADFIDR YSTPRMPWHD IGSVVHGKAA RDVARHFIQR WNFTKIMKPK YRSLSYPFLL 720
PKSQATAHEL RYQVPGAVHA KAQLLRSAAD WSAGIKHHEE SIHAAYTHVI ENSKHYIYIE 780
NQFFISCADD KVVFNKVGNA IAQRILKAHR EGQRYRVYIV IPLLPGFEGD ISTGGGNALQ 840
AIMHFNYRTM CRGESSILEQ LKPELGNKWI NYISFCGLRT HAELEGNLVT ELIYVHSKLL 900
IADDNTVIIG SANINDRSML GKRDSEMAVI VQDTETVPSV MDGKEYQAGR FAQGLRLECF 960
RLVLGYLSDP SEDIQDPVSD KFFKEIWVST AARNATIYDK VFRCLPNDEV HNLIQLRDFI 1020
NKPILAKEDR LRAEEELRKI RGFLVQFPFY FLSEENLLPS VGTKEAIVPM EVWT 1074 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0031985; C:Golgi cisterna; IDA:RGD.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0030027; C:lamellipodium; IDA:RGD.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0031982; C:vesicle; IDA:RGD.
 GO:0070290; F:NAPE-specific phospholipase D activity; IEA:EC.
 GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
 GO:0004630; F:phospholipase D activity; IDA:RGD.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0006654; P:phosphatidic acid biosynthetic process; IMP:MGI.
 GO:0009395; P:phospholipid catabolic process; IMP:RGD.
 GO:0030335; P:positive regulation of cell migration; IMP:RGD.
 GO:0043434; P:response to peptide hormone stimulus; IMP:RGD. 
Interpro
 IPR011993; PH_like_dom.
 IPR001683; Phox.
 IPR025202; PLD-like_dom.
 IPR001849; Pleckstrin_homology.
 IPR001736; PLipase_D/transphosphatidylase.
 IPR016555; PLipase_D_euk.
 IPR015679; PLipase_D_fam. 
Pfam
 PF00169; PH
 PF00614; PLDc
 PF13091; PLDc_2
 PF00787; PX 
SMART
 SM00233; PH
 SM00155; PLDc
 SM00312; PX 
PROSITE
 PS50003; PH_DOMAIN
 PS50035; PLD
 PS50195; PX 
PRINTS