UniProt Accession

 FIBG_HUMAN; P02679; A8K057; P04469; P04470; Q53Y18; Q96A14; Q96KJ3; Q9UC62; Q9UC63; Q9UCF3 

Genbank Protein ID

 M10014; M10014; AF118092; AF350254; AF350254; AK289422; AK290824; BT007081; CH471056; CH471056; BC007044; BC021674; X51473; X00086; K02569; K02569 

Genbank Nucleotide ID

 AAB59530.1; AAB59531.1; AAF22036.1; AAK19751.2; AAK19752.2; BAF82111.1; BAF83513.1; AAP35744.1; EAX04917.1; EAX04919.1; AAH07044.1; AAH21674.1; CAA35837.1; CAA24944.1; AAA52430.1; AAA52431.1 

Protein Name

 Fibrinogen gamma chain 

Protein Synonyms/Alias

  

Gene Name

 FGG 

Gene Synonyms/Alias

 PRO2061 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
196	QSGLYFIKPLKANQQ	acetylation	[1]
299	KVGPEADKYRLTYAY	acetylation	[1]
411	SMKKTTMKIIPFNRL	glycation	[2]

Reference

 [1] Acetylation and glycation of fibrinogen in vitro occur at specific lysine residues in a concentration dependent manner: a mass spectrometric and isotope labeling study.
 Svensson J, Bergman AC, Adamson U, Blombäck M, Wallén H, Jörneskog G.
 Biochem Biophys Res Commun. 2012 May 4;421(2):335-42. [PMID: 22507986]
 [2] Proteomic profiling of nonenzymatically glycated proteins in human plasma and erythrocyte membranes.
 Zhang Q, Tang N, Schepmoes AA, Phillips LS, Smith RD, Metz TO.
 J Proteome Res. 2008 May;7(5):2025-32. [PMID: 18396901] 

Functional Description

 Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. 

Sequence Annotation

 DOMAIN 170 416 Fibrinogen C-terminal.
 REGION 400 422 Gamma-chain polymerization, binding amino
 REGION 423 437 Platelet aggregation and Staphylococcus
 MOD_RES 444 444 Sulfotyrosine.
 MOD_RES 448 448 Sulfotyrosine.
 CARBOHYD 78 78 N-linked (GlcNAc...).
 CARBOHYD 334 334 N-linked (GlcNAc...); in variant Asahi.
 DISULFID 34 34 Interchain (with C-35).
 DISULFID 35 35 Interchain (with C-34).
 DISULFID 45 45 Interchain (with C-110 in beta chain).
 DISULFID 49 49 Interchain (with C-64 in alpha chain).
 DISULFID 161 161 Interchain (with C-227 in beta chain).
 DISULFID 165 165 Interchain (with C-180 in alpha chain).
 DISULFID 179 208
 DISULFID 352 365
 CROSSLNK 424 424 Isoglutamyl lysine isopeptide (Gln-Lys)
 CROSSLNK 432 432 Isoglutamyl lysine isopeptide (Lys-Gln)  

Keyword

 3D-structure; Alternative splicing; Blood coagulation; Calcium; Coiled coil; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Hemostasis; Isopeptide bond; Metal-binding; Polymorphism; Reference proteome; Secreted; Signal; Sulfation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 453 AA 

Protein Sequence

Gene Ontology

 GO:0072562; C:blood microparticle; IEA:Compara.
 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IDA:BHF-UCL.
 GO:0005577; C:fibrinogen complex; TAS:ProtInc.
 GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0030168; P:platelet activation; TAS:Reactome.
 GO:0002576; P:platelet degranulation; TAS:Reactome.
 GO:0051258; P:protein polymerization; IEA:InterPro.
 GO:0051592; P:response to calcium ion; IDA:BHF-UCL.
 GO:0007165; P:signal transduction; IEA:InterPro. 

Interpro

 IPR014716; Fibrinogen_a/b/g_C_1.
 IPR014715; Fibrinogen_a/b/g_C_2.
 IPR002181; Fibrinogen_a/b/g_C_dom.
 IPR012290; Fibrinogen_a/b/g_coil_dom.
 IPR020837; Fibrinogen_CS. 

Pfam

 PF08702; Fib_alpha
 PF00147; Fibrinogen_C 

SMART

 SM00186; FBG 

PROSITE

 PS00514; FIBRINOGEN_C_1
 PS51406; FIBRINOGEN_C_2 

PRINTS