UniProt Accession

 CISD3_HUMAN; P0C7P0 

Genbank Protein ID

 AC006449; BM546511 

Genbank Nucleotide ID

  

Protein Name

 CDGSH iron-sulfur domain-containing protein 3, mitochondrial 

Protein Synonyms/Alias

 MitoNEET-related protein 2; Miner2 

Gene Name

 CISD3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
48	VALKTPIKVELVAGK	acetylation	[1]
55	KVELVAGKTYRWCVC	acetylation	[2]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

  

Sequence Annotation

 METAL 60 60 Iron-sulfur 1 (2Fe-2S) (By similarity).
 METAL 62 62 Iron-sulfur 1 (2Fe-2S) (By similarity).
 METAL 71 71 Iron-sulfur 1 (2Fe-2S) (By similarity).
 METAL 75 75 Iron-sulfur 1 (2Fe-2S); via pros nitrogen
 METAL 98 98 Iron-sulfur 2 (2Fe-2S) (By similarity).
 METAL 100 100 Iron-sulfur 2 (2Fe-2S) (By similarity).
 METAL 109 109 Iron-sulfur 2 (2Fe-2S) (By similarity).
 METAL 113 113 Iron-sulfur 2 (2Fe-2S); via pros nitrogen
 MOD_RES 55 55 N6-acetyllysine.  

Keyword

 2Fe-2S; Acetylation; Complete proteome; Iron; Iron-sulfur; Metal-binding; Mitochondrion; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 127 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 

Interpro

 IPR018967; FeS-contain_CDGSH-typ.
 IPR006622; FeS-contain_CDGSH-typ_subfam. 

Pfam

 PF09360; zf-CDGSH 

SMART

 SM00704; ZnF_CDGSH 

PROSITE

  

PRINTS