UniProt Accession

 CD1E_HUMAN; P15812; B4DZV3; E7EP01; Q5TDJ9; Q5TDK3; Q5TDK4; Q5TDK5; Q5TDK6; Q5TDK8; Q5TDL1; Q712E4; Q712E5; Q712E6; Q712E7; Q712E8; Q712E9; Q712F0; Q712F1; Q712F2; Q712F3; Q712F4; Q712F5; Q96TD0; Q96TD1; Q9UMM1; Q9Y5M3 

Genbank Protein ID

 X14975; AJ289111; AJ289112; AJ289113; AJ289114; AJ289115; AJ289116; AJ289117; AJ289118; AJ289119; AJ289120; AJ289121; AJ289122; AK303108; AK311643; AL121986; AL121986; AL121986; AL121986; AL121986; AL121986; AL121986; AL121986; AL121986; AL121986; AL121986; AL121986; CH471121; CH471121; CH471121; CH471121; CH471121; CH471121; CH471121; CH471121; CH471121; CH471121; CH471121; AF142669; AH010757; AH010758; AJ251334; AJ251335; M14666 

Genbank Nucleotide ID

 CAA33100.1; CAB93150.1; CAB93151.1; CAB93152.1; CAB93153.1; CAB93154.1; CAB93155.1; CAB93156.1; CAB93157.1; CAB93158.1; CAB93159.1; CAB93160.1; CAB93161.1; BAG64215.1; CAI10854.1; CAI10855.1; CAI10856.1; CAI10857.1; CAI10858.1; CAI10859.1; CAI10860.1; CAI10861.1; CAI10862.1; CAI10863.1; CAI10864.1; CAI10865.1; EAW52828.1; EAW52830.1; EAW52831.1; EAW52832.1; EAW52833.1; EAW52834.1; EAW52835.1; EAW52837.1; EAW52838.1; EAW52839.1; EAW52840.1; AAD37582.1; AAK52913.1; AAK52914.1; CAB82829.1; CAC07175.1; AAA51937.1 

Protein Name

 T-cell surface glycoprotein CD1e, membrane-associated 

Protein Synonyms/Alias

 hCD1e; R2G1; CD1e; T-cell surface glycoprotein CD1e, soluble; sCD1e 

Gene Name

 CD1E 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
78	LGTIRFLKPWSHGNF	ubiquitination	[1]
170	IRAQNICKVLNRYLD	ubiquitination	[1]
179	LNRYLDIKEILQSLL	ubiquitination	[1]
206	EAGESELKRKVKPEA	ubiquitination	[1]
208	GESELKRKVKPEAWL	ubiquitination	[1]
210	SELKRKVKPEAWLSC	ubiquitination	[1]
336	LKKQSSNKNILSPHT	ubiquitination	[1]
358	GANTQDTKNSRHQFC	ubiquitination	[1, 2]
373	LAQVSWIKNRVLKKW	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane- associated form is not active. 

Sequence Annotation

 DOMAIN 191 301 Ig-like.
 CARBOHYD 47 47 N-linked (GlcNAc...) (Potential).
 CARBOHYD 84 84 N-linked (GlcNAc...) (Potential).
 DISULFID 230 285 By similarity.  

Keyword

 3D-structure; Adaptive immunity; Alternative splicing; Complete proteome; Disulfide bond; Endosome; Glycoprotein; Golgi apparatus; Immunity; Immunoglobulin domain; Lipid-binding; Lysosome; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 388 AA 

Protein Sequence

Gene Ontology

 GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
 GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
 GO:0019882; P:antigen processing and presentation; IEA:InterPro.
 GO:0006955; P:immune response; NAS:UniProtKB. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog. 

Pfam

 PF07654; C1-set 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE 

PRINTS