UniProt Accession

 F5GXH7_HUMAN; F5GXH7 

Genbank Protein ID

 AC114491; AL353892; AL391235; AL513206; AL591042 

Genbank Nucleotide ID

  

Protein Name

 Guanine nucleotide exchange factor VAV3 

Protein Synonyms/Alias

  

Gene Name

 VAV3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
139	FHIAENRKFKSLMEL	methylation	[1]
141	IAENRKFKSLMELVE	methylation	[1]
156	YYKHHSLKEGFRTLD	ubiquitination	[2]
171	TTLQFPYKEPEHSAG	ubiquitination	[2]
192	GNSLLSPKVLGIAIA	ubiquitination	[2, 3]
215	MRELSLLKGDVVKIY	ubiquitination	[2]
224	DVVKIYTKMSANGWW	ubiquitination	[2]

Reference

 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome; SH3 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 251 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IEA:Compara.
 GO:0016477; P:cell migration; IEA:Compara.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:Compara.
 GO:0030032; P:lamellipodium assembly; IEA:Compara.
 GO:0045785; P:positive regulation of cell adhesion; IEA:Compara.
 GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IEA:Compara.
 GO:0043087; P:regulation of GTPase activity; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:Compara.
 GO:0006906; P:vesicle fusion; IEA:Compara. 

Interpro

 IPR000980; SH2.
 IPR011511; SH3_2.
 IPR001452; SH3_domain.
 IPR013315; Spectrin_alpha_SH3. 

Pfam

 PF00017; SH2
 PF07653; SH3_2 

SMART

 SM00252; SH2
 SM00326; SH3 

PROSITE

 PS50001; SH2
 PS50002; SH3 

PRINTS

 PR00401; SH2DOMAIN.
 PR00452; SH3DOMAIN.
 PR01887; SPECTRNALPHA.