UniProt Accession

 RAB18_PONAB; Q5R5H5 

Genbank Protein ID

 CR860884 

Genbank Nucleotide ID

 CAH92991.1 

Protein Name

 Ras-related protein Rab-18 

Protein Synonyms/Alias

  

Gene Name

 RAB18 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 

NCBI Taxa ID

 9601 

Lysine Modification

Position	Peptide	Type	References
183	WESENQNKGVKLSHR	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity). 

Sequence Annotation

 NP_BIND 15 23 GTP (By similarity).
 NP_BIND 63 67 GTP (By similarity).
 NP_BIND 122 125 GTP (By similarity).
 NP_BIND 151 153 GTP (By similarity).
 MOTIF 37 45 Effector region (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 203 203 Cysteine methyl ester (Potential).
 LIPID 199 199 S-palmitoyl cysteine (Potential).
 LIPID 203 203 S-geranylgeranyl cysteine (By  

Keyword

 Acetylation; Complete proteome; Developmental protein; GTP-binding; Lipoprotein; Methylation; Nucleotide-binding; Palmitate; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 206 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:Compara.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007420; P:brain development; ISS:UniProtKB.
 GO:0001654; P:eye development; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR025662; Sigma_54_int_dom_ATP-bd_1.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.