UniProt Accession

 OAZ1_MOUSE; P54369; O08610 

Genbank Protein ID

 U52822; U52823; U84291 

Genbank Nucleotide ID

 AAB96329.1; AAB96330.1; AAC53307.1 

Protein Name

 Ornithine decarboxylase antizyme 1 

Protein Synonyms/Alias

 ODC-Az 

Gene Name

 Oaz1 

Gene Synonyms/Alias

 Oaz 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
112	EEPTSNDKTRVLSIQ	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome; Ribosomal frameshifting. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 227 AA 

Protein Sequence

Gene Ontology

 GO:0008073; F:ornithine decarboxylase inhibitor activity; IGI:MGI.
 GO:0006595; P:polyamine metabolic process; TAS:MGI. 

Interpro

 IPR016181; Acyl_CoA_acyltransferase.
 IPR002993; ODC_AZ. 

Pfam

 PF02100; ODC_AZ 

SMART

  

PROSITE

 PS01337; ODC_AZ 

PRINTS