CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023116
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Long-chain-fatty-acid--CoA ligase 6 
Protein Synonyms/Alias
 Long-chain acyl-CoA synthetase 6; LACS 6 
Gene Name
 ACSL6 
Gene Synonyms/Alias
 ACS2; FACL6; KIAA0837; LACS5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
381RLLSDDMKALCPTIFubiquitination[1]
420WLLEFAAKRKQAEVRubiquitination[1]
576WLPAGTLKIIDRKKHubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. 
Sequence Annotation
  
Keyword
 Alternative splicing; ATP-binding; Chromosomal rearrangement; Complete proteome; Endoplasmic reticulum; Fatty acid metabolism; Ligase; Lipid metabolism; Magnesium; Membrane; Microsome; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Peroxisome; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 697 AA 
Protein Sequence
MLTFFLVSGG SLWLFVEFVL SLLEKMQTQE ILRILRLPEL GDLGQFFRSL SATTLVSMGA 60
LAAILAYWFT HRPKALQPPC NLLMQSEEVE DSGGARRSVI GSGPQLLTHY YDDARTMYQV 120
FRRGLSISGN GPCLGFRKPK QPYQWLSYQE VADRAEFLGS GLLQHNCKAC TDQFIGVFAQ 180
NRPEWIIVEL ACYTYSMVVV PLYDTLGPGA IRYIINTADI STVIVDKPQK AVLLLEHVER 240
KETPGLKLII LMDPFEEALK ERGQKCGVVI KSMQAVEDCG QENHQAPVPP QPDDLSIVCF 300
TSGTTGNPKG AMLTHGNVVA DFSGFLKVTE KVIFPRQDDV LISFLPLAHM FERVIQSVVY 360
CHGGRVGFFQ GDIRLLSDDM KALCPTIFPV VPRLLNRMYD KIFSQANTPL KRWLLEFAAK 420
RKQAEVRSGI IRNDSIWDEL FFNKIQASLG GCVRMIVTGA APASPTVLGF LRAALGCQVY 480
EGYGQTECTA GCTFTTPGDW TSGHVGAPLP CNHIKLVDVE ELNYWACKGE GEICVRGPNV 540
FKGYLKDPDR TKEALDSDGW LHTGDIGKWL PAGTLKIIDR KKHIFKLAQG EYVAPEKIEN 600
IYIRSQPVAQ IYVHGDSLKA FLVGIVVPDP EVMPSWAQKR GIEGTYADLC TNKDLKKAIL 660
EDMVRLGKES GLHSFEQVKA IHIHSDMFSV QNGLLTPTLK AKRPELREYF KKQIEELYSI 720
SM 722 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; NAS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004467; F:long-chain fatty acid-CoA ligase activity; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0032869; P:cellular response to insulin stimulus; IEA:Compara.
 GO:0015908; P:fatty acid transport; IEA:Compara.
 GO:0035338; P:long-chain fatty-acyl-CoA biosynthetic process; TAS:Reactome.
 GO:0007405; P:neuroblast proliferation; IEA:Compara.
 GO:0048666; P:neuron development; IEA:Compara.
 GO:0008654; P:phospholipid biosynthetic process; IEA:Compara.
 GO:0010976; P:positive regulation of neuron projection development; IEA:Compara.
 GO:0010747; P:positive regulation of plasma membrane long-chain fatty acid transport; IEA:Compara.
 GO:0010867; P:positive regulation of triglyceride biosynthetic process; IEA:Compara.
 GO:0009629; P:response to gravity; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0048545; P:response to steroid hormone stimulus; IEA:Compara.
 GO:0019432; P:triglyceride biosynthetic process; TAS:Reactome. 
Interpro
 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig. 
Pfam
 PF00501; AMP-binding 
SMART
  
PROSITE
 PS00455; AMP_BINDING 
PRINTS