UniProt Accession

 C9JNR4_HUMAN; C9JNR4 

Genbank Protein ID

 AC104452; AC121247; AC137114 

Genbank Nucleotide ID

  

Protein Name

 Transforming protein RhoA 

Protein Synonyms/Alias

  

Gene Name

 RHOA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
104	EKWTPEVKHFCPNVP	ubiquitination	[1, 2]
118	PIILVGNKKDLRNDE	ubiquitination	[3, 4]
119	IILVGNKKDLRNDEH	methylation	[5]
119	IILVGNKKDLRNDEH	ubiquitination	[2, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; GTP-binding; Membrane; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 129 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0032587; C:ruffle membrane; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:Compara.
 GO:0030521; P:androgen receptor signaling pathway; IEA:Compara.
 GO:0043297; P:apical junction assembly; IEA:Compara.
 GO:0007160; P:cell-matrix adhesion; IEA:Compara.
 GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0033144; P:negative regulation of intracellular steroid hormone receptor signaling pathway; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0045665; P:negative regulation of neuron differentiation; IEA:Compara.
 GO:0048812; P:neuron projection morphogenesis; IEA:Compara.
 GO:0043931; P:ossification involved in bone maturation; IEA:Compara.
 GO:0030838; P:positive regulation of actin filament polymerization; IEA:Compara.
 GO:0045785; P:positive regulation of cell adhesion; IEA:Compara.
 GO:0030307; P:positive regulation of cell growth; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Compara.
 GO:0071803; P:positive regulation of podosome assembly; IEA:Compara.
 GO:0045727; P:positive regulation of translation; IEA:Compara.
 GO:0045907; P:positive regulation of vasoconstriction; IEA:Compara.
 GO:0051924; P:regulation of calcium ion transport; IEA:Compara.
 GO:0050773; P:regulation of dendrite development; IEA:Compara.
 GO:0033688; P:regulation of osteoblast proliferation; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0043200; P:response to amino acid stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0007519; P:skeletal muscle tissue development; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO:0043149; P:stress fiber assembly; IEA:Compara.
 GO:0031098; P:stress-activated protein kinase signaling cascade; IEA:Compara.
 GO:0061383; P:trabecula morphogenesis; IEA:Compara. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 

Pfam

 PF00071; Ras 

SMART

 SM00174; RHO 

PROSITE

 PS51420; RHO 

PRINTS

 PR00449; RASTRNSFRMNG.