UniProt Accession

 RT102_YEAST; P53330; D6VV52 

Genbank Protein ID

 X84098; Z73060; AY558382; BK006941 

Genbank Nucleotide ID

 CAA58897.1; CAA97305.1; AAS56708.1; DAA08363.1 

Protein Name

 Regulator of Ty1 transposition protein 102 

Protein Synonyms/Alias

  

Gene Name

 RTT102 

Gene Synonyms/Alias

 YGR275W; G9378 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
55	DMENNLEKYPFRYKT	acetylation	[1]
107	HTKGDTSKATGAPSA	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Probable component of the chromatin structure-remodeling complex (RSC) which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. Probable component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA- histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors. 

Sequence Annotation

 MOD_RES 77 77 Phosphoserine.
 MOD_RES 122 122 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 157 AA 

Protein Sequence

Gene Ontology

 GO:0016586; C:RSC complex; IDA:SGD.
 GO:0016514; C:SWI/SNF complex; IDA:SGD.
 GO:0006338; P:chromatin remodeling; IC:SGD.
 GO:0007059; P:chromosome segregation; IMP:SGD.
 GO:0006337; P:nucleosome disassembly; IDA:SGD.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; IDA:SGD. 

Interpro

 IPR018304; Tscrpt_reg_Rtt102p. 

Pfam

 PF09510; Rtt102p 

SMART

  

PROSITE

  

PRINTS