CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011954
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Forkhead box protein F2 
Protein Synonyms/Alias
 Forkhead-related activator 2; FREAC-2; Forkhead-related protein FKHL6; Forkhead-related transcription factor 2 
Gene Name
 FOXF2 
Gene Synonyms/Alias
 FKHL6; FREAC2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
204RRKCQALKPMYHRVVacetylation[1]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 
Functional Description
 Probable transcription activator for a number of lung- specific genes. 
Sequence Annotation
 DNA_BIND 99 190 Fork-head.  
Keyword
 Activator; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 444 AA 
Protein Sequence
MTTEGGPPPA PLRRACSPVP GALQAALMSP PPAAAAAAAA APETTSSSSS SSSASCASSS 60
SSSNSASAPS AACKSAGGGG AGAGSGGAKK ASSGLRRPEK PPYSYIALIV MAIQSSPSKR 120
LTLSEIYQFL QARFPFFRGA YQGWKNSVRH NLSLNECFIK LPKGLGRPGK GHYWTIDPAS 180
EFMFEEGSFR RRPRGFRRKC QALKPMYHRV VSGLGFGASL LPQGFDFQAP PSAPLGCHSQ 240
GGYGGLDMMP AGYDAGAGAP SHAHPHHHHH HHVPHMSPNP GSTYMASCPV PAGPGGVGAA 300
GGGGGGDYGP DSSSSPVPSS PAMASAIECH SPYTSPAAHW SSPGASPYLK QPPALTPSSN 360
PAASAGLHSS MSSYSLEQSY LHQNAREDLS VGLPRYQHHS TPVCDRKDFV LNFNGISSFH 420
PSASGSYYHH HHQSVCQDIK PCVM 444 
Gene Ontology
 GO:0005667; C:transcription factor complex; IDA:UniProtKB.
 GO:0008301; F:DNA binding, bending; IBA:RefGenome.
 GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
 GO:0009790; P:embryo development; IBA:RefGenome.
 GO:0048596; P:embryonic camera-type eye morphogenesis; IEA:Compara.
 GO:0048566; P:embryonic digestive tract development; IEA:Compara.
 GO:0001837; P:epithelial to mesenchymal transition; NAS:UniProtKB.
 GO:0042249; P:establishment of planar polarity of embryonic epithelium; IEA:Compara.
 GO:0030198; P:extracellular matrix organization; IEA:Compara.
 GO:0048806; P:genitalia development; IMP:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0060021; P:palate development; IMP:UniProtKB.
 GO:0007389; P:pattern specification process; IBA:RefGenome.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome. 
Interpro
 IPR001766; TF_fork_head.
 IPR018122; TF_fork_head_CS.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00250; Fork_head 
SMART
 SM00339; FH 
PROSITE
 PS00657; FORK_HEAD_1
 PS00658; FORK_HEAD_2
 PS50039; FORK_HEAD_3 
PRINTS
 PR00053; FORKHEAD.