UniProt Accession

 ASGR1_RAT; P02706 

Genbank Protein ID

 K02817; BC088154; M21770 

Genbank Nucleotide ID

 AAA42037.1; AAH88154.1; AAA40764.1 

Protein Name

 Asialoglycoprotein receptor 1 

Protein Synonyms/Alias

 ASGP-R 1; ASGPR 1; Hepatic lectin 1; HL-1; rHL-1 

Gene Name

 Asgr1 

Gene Synonyms/Alias

 Asgr-1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
102	ERVGRKMKLVESQLE	acetylation	[1]
110	LVESQLEKHQEDLRE	acetylation	[1]
127	SRLLLHVKQLVSDVR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. 

Sequence Annotation

 DOMAIN 160 277 C-type lectin.
 MOTIF 5 8 Endocytosis signal (Potential).
 METAL 190 190 Calcium 1; via carbonyl oxygen (By
 METAL 196 196 Calcium 1 (By similarity).
 METAL 215 215 Calcium 2 (By similarity).
 METAL 239 239 Calcium 3 (By similarity).
 METAL 241 241 Calcium 3 (By similarity).
 METAL 242 242 Calcium 2 (By similarity).
 METAL 252 252 Calcium 2; via carbonyl oxygen (By
 METAL 252 252 Calcium 3 (By similarity).
 METAL 253 253 Calcium 2 (By similarity).
 METAL 264 264 Calcium 3 (By similarity).
 METAL 265 265 Calcium 3 (By similarity).
 METAL 277 277 Calcium 1 (By similarity).
 BINDING 239 239 Carbohydrate (By similarity).
 BINDING 243 243 Carbohydrate (By similarity).
 BINDING 252 252 Carbohydrate (By similarity).
 LIPID 35 35 S-palmitoyl cysteine.
 CARBOHYD 75 75 N-linked (GlcNAc...) (Potential).
 CARBOHYD 78 78 N-linked (GlcNAc...) (Potential).
 CARBOHYD 146 146 N-linked (GlcNAc...) (Potential).
 DISULFID 153 164 By similarity.
 DISULFID 181 276 By similarity.
 DISULFID 254 268 By similarity.  

Keyword

 Calcium; Coiled coil; Complete proteome; Disulfide bond; Endocytosis; Glycoprotein; Lectin; Lipoprotein; Membrane; Metal-binding; Palmitate; Phosphoprotein; Receptor; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 284 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004873; F:asialoglycoprotein receptor activity; IDA:RGD.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0031668; P:cellular response to extracellular stimulus; IEA:Compara. 

Interpro

 IPR001304; C-type_lectin.
 IPR016186; C-type_lectin-like.
 IPR018378; C-type_lectin_CS.
 IPR016187; C-type_lectin_fold.
 IPR005640; Lectin_N. 

Pfam

 PF00059; Lectin_C
 PF03954; Lectin_N 

SMART

 SM00034; CLECT 

PROSITE

 PS00615; C_TYPE_LECTIN_1
 PS50041; C_TYPE_LECTIN_2 

PRINTS