UniProt Accession

 HMGN5_MOUSE; Q9JL35; O88832; Q3V272; Q8VC71; Q9CUW1 

Genbank Protein ID

 AF213454; AB018374; AK013748; AK131996; AL954348; BC021626; BC083087 

Genbank Nucleotide ID

 AAF30179.1; BAA33783.2; BAB28982.2; BAE20926.1; CAM15237.1; AAH21626.1; AAH83087.1 

Protein Name

 High mobility group nucleosome-binding domain-containing protein 5 

Protein Synonyms/Alias

 Nucleosome-binding protein 1; Nucleosome-binding protein 45; NBP-45; Protein GARP45 

Gene Name

 Hmgn5 

Gene Synonyms/Alias

 Garp45; Nsbp1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
15	GDVSQEPKRRSARLS	acetylation	[1]
33	VPFTPELKPKRASTS	acetylation	[2]
33	VPFTPELKPKRASTS	ubiquitination	[3]
91	IMEAPIPKMEAEEVK	ubiquitination	[3]
98	KMEAEEVKEQINEDT	ubiquitination	[3]
161	EEEGLNEKPGTAKSE	ubiquitination	[3]
281	IHHEEDGKEGQPEED	ubiquitination	[3]
304	DGEEGQPKEDQKEGQ	ubiquitination	[3]
326	DQPEEDGKEGQCKED	ubiquitination	[3]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction. 

Sequence Annotation

 MOD_RES 18 18 Phosphoserine.
 MOD_RES 22 22 Phosphoserine.
 MOD_RES 29 29 Phosphothreonine.
 MOD_RES 167 167 Phosphoserine.
 MOD_RES 376 376 Phosphoserine.  

Keyword

 Chromatin regulator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; IEA:InterPro.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005654; C:nucleoplasm; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0031492; F:nucleosomal DNA binding; IEA:InterPro.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000079; HMGN_fam. 

Pfam

 PF01101; HMG14_17 

SMART

 SM00527; HMG17 

PROSITE

 PS00355; HMG14_17 

PRINTS

 PR00925; NONHISHMG17.