CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011691
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TBC1 domain family member 8B 
Protein Synonyms/Alias
  
Gene Name
 TBC1D8B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
118ITNFVQGKIRGLIAEubiquitination[1, 2]
258AIRRLFDKETFDNDPubiquitination[1]
275YNPLQITKRGLENRAubiquitination[1, 2]
375AFRFHEVKDFEQLVAubiquitination[1]
383DFEQLVAKLRLRCGAubiquitination[1]
716FFDNVTNKDSPLPSNubiquitination[1, 2]
734GSNVSDEKTSHTRVDubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 May act as a GTPase-activating protein for Rab family protein(s). 
Sequence Annotation
 DOMAIN 145 212 GRAM 1.
 DOMAIN 285 353 GRAM 2.
 DOMAIN 487 674 Rab-GAP TBC.
 DOMAIN 858 893 EF-hand.  
Keyword
 Alternative splicing; Complete proteome; GTPase activation; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1120 AA 
Protein Sequence
MWLKPEEVLL KNALKLWLME RSNDYFVLQR RRGYGEEGGG GLTGLLVGTL DSVLDSTAKV 60
APFRILHQTP DSQVYLSIAC GANREEITKH WDWLEQNIMK TLSVFDSNED ITNFVQGKIR 120
GLIAEEGKHC FAKEDDPEKF REALLKFEKC FGLPEKEKLV TYYSCSYWKG RVPCQGWLYL 180
STNFLSFYSF LLGSEIKLII SWDEVSKLEK TSNVILTESI HVCSQGENHY FSMFLHINQT 240
YLLMEQLANY AIRRLFDKET FDNDPVLYNP LQITKRGLEN RAHSEQFNAF FRLPKGESLK 300
EVHECFLWVP FSHFNTHGKM CISENYICFA SQDGNQCSVI IPLREVLAID KTNDSSKSVI 360
ISIKGKTAFR FHEVKDFEQL VAKLRLRCGA ASTQYHDIST ELAISSESTE PSDNFEVQSL 420
TSQRECSKTV NTEALMTVFH PQNLETLNSK MLKEKMKEQS WKILFAECGR GVSMFRTKKT 480
RDLVVRGIPE TLRGELWMLF SGAVNDMATN PDYYTEVVEQ SLGTCNLATE EIERDLRRSL 540
PEHPAFQSDT GISALRRVLT AYAYRNPKIG YCQAMNILTS VLLLYAKEEE AFWLLVAVCE 600
RMLPDYFNRR IIGALVDQAV FEELIRDHLP QLTEHMTDMT FFSSVSLSWF LTLFISVLPI 660
ESAVNVVDCF FYDGIKAILQ LGLAILDYNL DKLLTCKDDA EAVTALNRFF DNVTNKDSPL 720
PSNVQQGSNV SDEKTSHTRV DITDLIRESN EKYGNIRYED IHSMRCRNRL YVIQTLEETT 780
KQNVLRVVSQ DVKLSLQELD ELYVIFKKEL FLSCYWCLGC PVLKHHDPSL PYLEQYQIDC 840
QQFRALYHLL SPWAHSANKD SLALWTFRLL DENSDCLINF KEFSSAIDIM YNGSFTEKLK 900
LLFKLHIPPA YTEVKSKDAS KGDELSKEEL LYFSQLHVSK PANEKEAESA KHSPEKGKGK 960
IDIQAYLSQW QDELFKKEEN IKDLPRMNQS QFIQFSKTLY NLFHEDPEEE SLYQAIAVVT 1020
SLLLRMEEVG RKLHSPTSSA KGFSGTVCGS GGPSEEKTGS HLEKDPCSFR EEPQWSFAFE 1080
QILASLLNEP ALVRFFEKPI DVKAKLENAR ISQLRSRTKM 1120 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom.
 IPR004182; GRAM.
 IPR000195; Rab-GTPase-TBC_dom. 
Pfam
 PF02893; GRAM
 PF00566; RabGAP-TBC 
SMART
 SM00568; GRAM
 SM00164; TBC 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50086; TBC_RABGAP 
PRINTS